Anoplocephalatoses (monieziozis, thyzanieziozis, avitellinozis) are cestodozes which put considerable negative impact on sheep-breading. Monieziozis causes the highest damages from them. The lambs are ill mainly at the age of 1,5–8months. This helminthosis passes among young animals in the form of enzootia as rule. Also it is accompanied by considerable mortality.

In basis of treatment is presence a monoinvasion or poliinvasion, the spectrum of action of remedy, the organism of animals, the physiology state of animals and other factors. The protracted application of remedies causes the rice of cultures of tapeworms which are steadfast for their action. In addition the application of anthelmintics draws the immunosuppression.

The problem of correct choice of anthelmintics is extraordinary actual today because amount of anthelmintic remedies grows constantly in market. One of them have the narrow spectrum of action, the other have the long time of selected from an organism, the third have side effects and complications.

It is well known that anthelmintics can render negative influence on the organism of animals. That is determined by disturbing of their application, by low chemotherapeutic index, the presence of embriotropy properties and local action of remedies.

We made experiment on 20 heads of lambs in age 4–6 month with the purpose of determination the most effective remedy among the known existing. We give for animals such modern anthelmintics as Albendazol-L 7,5% with forage in dose of 0,7 g/10 kg of weight (the first experimental group); Rafenzol from the calculation of 1 ml/10 kg of weight (it contain rafoksanid – 110 mg, fenbendazol – 75 mg, levamisol hydrochloride – 3 mg, wather distillated – to 1 ml) for animals of second experimental group; Phenasal (contains 94% of niklozamid) was set individually from a rubber bottle in dose per 0,1 g/kg of weight of animal as 1% of starched suspension (the third experimental group). The animals of control group weren’t processed by anthelmintic remedies.

We conducted the clinical review of lambs daily after introduction of remedies. We conducted the visual review of matter at 1, 3, 5 and 10 days. Also we investigated excrements by method of Fulleborn with the purpose to definition the ekstenseffectivity of remedies.

After treatment of animals of first experimental group by Albendazol-L 7,5%, second experimental group by Rafenzol, third – by Phenasal already on the first day after treatment one animal from the first group, two animals from the second group and two animals from the third experimental group freed from causative agent The ekstenseffectivity made 20, 40, and 40% accordingly. The indexes of extensivity of invasia remained without changes among the animals of control group.

On the 3rd day after treatment the greatest ekstenseffectivity was for Rafenzol (80%). The animals from the second experimental group were processed by it. This proof was 60% among the animals from the first and third experimental groups (it thus that Rafenzol is considered as anthelmintic which is applied at nemathodoses; but it contains the fenbendazol, which have action for tapeworms).

The ekstenseffectivity was 100% for animals of second experimental group, it was 80% for the animals from the third experimental group and the lowest ekstenseffectivity was for Albendazol-L 7,5% (among the animals from the first experimental group) on the 3rd day after treatment. It should be noted that exactly remedies the operating matter of which is albendazol are used in an economy during the last ten years.

The ekstenseffectivity was 100% for Rafenzol and Phenasal and it was 80% for Albendazol-L 7,5 % on the 10th day after treatment.

The indexes of extensivity and intensivity of invasia did not change at the end of experience among the animals from the control group (the animals of this group were not treated by anthelmintics).

So the preparation of Albendazol-L 7,5 % that is widely used in market during the last 10 years appeared the least effective for treatment of anoplocephalatoses of sheep in comparing to Rafenzol and Phenasal. It can be connected with the firmness emergence of tapeworms for this remedies. Rafenzol appeared most effective (the ekstenseffectivity was 100 % on the 5th day). The index of ekstenseffectivity appeared the same for Phenasal but only on a 10th day.

Thus Rafenzol is appeared the most effective for lambs in age 4–6 month with the purpose of treatment of spontaneous anoplocephalatoses.

The remedies with albendazol are widely used in this region for treatment of anoplocephalatoses but they show considerably less efficiency (ekstenseffectivity 80% on the 10th day after dehelmintization). It can be explained with firmness emergence of tapeworms to the action of this medical basis.

Phenasal is high-efficiency for treatment of anoplocephalatoses. But liberation from helmints comes at the 10th day after processing. As for Rafenzol the liberation from helmints comes in the 5th day after treatment.

Key words: anoplocephalatoses, cestodoses, antgelmintic, ekstenseffektivity, sheep.