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Study of effectiveness of antibacterial preparation Everodox-LA in broiler chickens
Poultry farming is one of the most intensive industries in the Republic of Belarus. For everyone produced 29 kilograms of poultry meat and 356 eggs per year, at the beginning of 2011 all poultry farms of Republic were 31,2 million birds.
The agricultural enterprises produced 97% of poultry meat and more than 65% of eggs. Supplementation of this product to population with quality poultry products for future required designed «Poultry Development Program in Belarus», which provides for an annual increase in of poultry production in live weight not less than 15%.
According to information provided by the Directorate General of animal industry, intensification the results of the poultry farms of the Republic of Belarus for 2013 produced poultry meat chickens-broilers 468 284,9 tons (109% in 2012), average daily gain and survival of birds 59,0 grams and 94,1 % respectively. January 01, 2013 in Belarus had 9 133,9 thousand layer chickens (120 % in 2012), eggs produced about 2,437,881 eggs (107% in 2012), egg-laying was on average 303 eggs (in 2012 – 307,6 eggs).
Antibiotics are used for different purposes in the poultry industry, which include not only the treatment or prevention of infections, but also in the use of sub-therapeutic dose in feed for poultry and animals to promote growth and improve feed efficiency in modern intensifying agricultural production.
Antibiotics are antimicrobials produced by microorganisms that inhibit the growth or destroy pathogenic bacteria used for the treatment of infectious diseases of humans, animals or plants (Abramson, A.J.M., 2007).Nine classes of antibiotics used for animals but only a few classes are usually prescribed for animals and for humans: penicillines, cephalosporines, tetracycline, chloramphenicol, aminoglycosides, macrolides, nitrofuranes, nitroimidazoles, sulfonamides, trimethoprim, polymyxines and quinolones
Aim of our research is to determine the sensitivity of infectional diseases with bacterial etiology of broiler chickens to antibiotics «Everodox-LA» in laboratory and study its effect in farm.
Antibacterial preparation «Everodox-LA» is a sterile clear solution, 1 cm3 of a solution containing 200 mg doxycycline monohydrate and doxycycline as an injectable solution.«Everodox-LA» in antibacterial preparation, mechanism of its effect is due to the constituent parts. Doxycycline is a broad-spectrum antibiotic tetracycline, which has bactericidal effect. Tetracyclines inhibit protein synthesis in bacteria by binding to ribosomal subunits 5OS, preventing their binding of aminoacyl-tRNA.
Therapeutic dose for chickens and turkeys is 50–100 mg of doxycycline per 1 liter of drinking water. This dose is achieved by the addition of 0,5–1 ml «Everodox-LA» in 1 liter of drinking water. Therapy was continued for 3–5 days, the amount of preparation required for the treatment of birds, are mixed with sufficient water.
At the beginning of conducted scientific laboratory experiment to determinate sensitivity of microorganisms, isolated from birds from poultry farms in the Republic of Belarus, to antibiotics «Everodox-LA».
Records of the results were carried out according to the diameter of the zone growth inhibition of sensitive isolates. When evaluation the sensitivity of microorganisms, isolated from birds from poultry farms in the Republic of Belarus, found that a preparation «Everodox-LA» and its analogues were highly sensitive to following microorganisms: Salmonella enteritidis, Salmonella typhimurium, Salmonella pullorum - gallinarum, Escherichia coli, Staphylococcus aureus, Streptococcus faecalis, Pasteurellamultocida, Chlamydia psittaci, Bordetellaavium; showed high sensitivity – Mycoplasma synoviae, Clostridium perfringens; low sensitivity – Pseudomonas aeruginosa.
Study the effectiveness of preparation «Everodox-LA» in birds with bacterial infectious disease conducted in experiment under industrials conditions in two trials and the results show the usefulness of antibacterial drug «Everodox-LA» in these conditions throughout the growing period for the treatment and prevention of bacterial infections, improve survival rate, average body weight and average daily gain of birds. Indicators of the experimental group were higher than the control for the survival rate and growth rate of birds, survival rate was 96,0 % while 94,9 % in control (in 1sttrial) and 95,2% in control (in 2ndtrial).
Key words: Broiler-chickens, «Everodox-LA», antibacterial preparation, antibiotic sensitivity test, survival ratio.
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