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Acellular probiotics and asparagic acid in the prevention of postpartum endometritis in cows
Postpartum endometritis is one of the most widespread pathologies in animal husbandry. They often occur on the background of exposure on animals stress factors, microclimate disorders, complete feeding, which is accompanied by decrease of the resistance, leads to increasing morbidity, etc. The aim of the research is to develop a method of prevention of postpartum endometritis in cows using cell-free probiotics "Bacinil" and "Lactimet" with 4 % suspension of aspartic acid. Complex use of integrated cell-free probiotics "Bacinyl" and "Lactimet" with 4% suspension of asparagic acid for the prevention of postpartum endometritis in doses of 7.5 and 10 ml each at 3-fold use once a day for 3 days in a row allowed to obtain 100% preventive effi cacy. The mechanism of action of probiotic "Bacinil" is based on the high activity of components of its composition - immunostimulants (lipopolysaccharides), bacteriocins and enzymes, probiotic "Lactimet" due to biosynthetic lactic acid and a complex of fermentation products. Complex application of probiotics and aspartic acid increases their bacteriostatic activity, which allows more actively suppress the proliferation of pathogenic and opportunistic microflora, complicating the flowing of postpartum endometritis; promotes liquefaction of exudate accumulated in the uterine cavity due to enzymes included in probiotic "Bacinil"; leads to activation of local immunity of endometrial tissues due to immunostimulating activity of components of "Bacinil" and "Lactimet" probiotics; creation of low pH level in the uterine cavity due to aspartic acid and biosynthetic lactic acid.
Key words: cows, postpartum endometritis, prophylaxis, acellular probiotics, aspartic acid.
REFERENCES
1. Krasochko, P.A. (2016). Veterinarnye i tehnologicheskie meroprijatija pri soderzhanii krupnogo rogatogo sko-ta: monografija [Veterinary and technological measures for keeping cattle: monograph]. Smolensk: "Universe", 508 p.
2. Yatsyna, V.V., Shchigelskaya, E.S., Ostroukhov, I.Yu. (2020). Patologija matki u korov, profilaktika i lechenie [Uterine pathology in cows, prevention and treatment]. Uchenye zapiski UO VGAVM [Scientific notes of the UO VGAVM]. Smolensk: "Universe", Vol. 56, no. 2, pp. 54–58.
3. Fiziologicheskie osnovy projavlenija stressov i puti ih korrekcii v promyshlennom zhivotnovodstve: mono-grafija. V 2 ch. Ch. 1 / F.I.Furduj i dr. Pod red. P.A.Krasoch-ko [Physiological bases of stress manifestation and ways of their correction in industrial animal husbandry: monograph. At 2 pm Part 1 / FI Furdui and others / Ed. P.A. Krasochko]. Gorki: BGSKhA, 2013, 564 p.
4. Fiziologicheskie osnovy proyavleniya stressov i puti ih korrekcii v promyshlennom zhivotnovodstve: monografiya. V 2 ch. CH. 2 / F.I.Furduj i dr. Pod red. P.A.Krasochko [Physiological bases of stress manifestation and ways of their correction in industrial animal husbandry: monograph. At 2 pm Part 1 / FI Furdui and others. Ed. P.A. Krasochko]. Gorki: BGSKhA, 2013, 492 p.
5. Eremin, S.P., Bezrukova, T.S., Yashin, I.V. (2017). Profilaktika zabolevanij korov v poslerodovyj period [Prevention of diseases in cows in the postpartum period]. [Prospects and current problems of the development of highly productive dairy and beef cattle breeding: materials of the International Scientific and Practical Conference, Vitebsk, May 25-27 2017 / UO VGAVM; editorial board: NI Gavrichenko (chief editor) and others. Vitebsk, pp. 58–60.
6. Sergeev, V.I., Stravsky, Y.S., Sachuk, R.N. (2019). Vliyanie preparata «Gepaveks 200» na soderzhanie ob-shchego belka i ego frakcij v organizme korov v poslero-dovom periode [Influence of the drug "Gepavex 200" on the content of total protein and its fractions in the body of cows in the postpartum period]. Uchenye zapiski UO VGAVM [Scientific notes of the UO VGAVM]. Vol. 55, no. 1, pp. 88–91.
7. RU 2538804 C1, A61K 35/74, A61R 15/00, opubl.
10.01.2015. Byul. № 1 [RU 2538804 C1, A61K 35/74, A61P 15/00, publ. 10.01.2015. Bul. No. 1].
8. RU 2 693 900 C1, A61K 31/138(2006.01), A61K 35/742(2015.01), A61K 35/744(2015.01)0 A61K 47/44(2006.01), A61P 15/00(2006.01), opubl. 05.07.2019. Byul. №19 [RU 2 693 900 C1, A61K 31/138 (2006.01), A61K 35/742 (2015.01), A61K 35/744 (2015.01) 0 A61K 47/44 (2006.01), A61P 15/00 (2006.01), publ. 07/05/2019. Bul. No. 19].
9. Patent Ukrainy №UA14569. Biopreparat dlya lech-eniya i profilaktiki endometritov zhivotnyh. Data publikacii
15.05.2006. [Patent of Ukraine No. UA14569. Biological product for the treatment and prevention of animal endome-tritis. Date of publication May 15, 2006.].
10. Bondarev, I.V., Mikhalev, V.I., Tolkachev, I.S. (2019). Strukturnaya organizaciya endometriya korov pri hronicheskih vospalitel'nyh zabolevaniyah matki [Structural organization of cow endometrium in chronic inflammatory diseases of the uterus]. Uchenye zapiski UO VGAVM [Scientific notes of the UO VGAVM]. Vol. 55, no. 4, pp. 15–19.
11. Patent RF №45289 na poleznuyu model' Suppozi-torii «Vetomgin» dlya profilaktiki i lecheniya urogenital'nyh zabolevanij. Data publikacii 10.05.2005 [RF patent №45289 for a useful model "Vetomgin" suppositories for the prevention and treatment of urogenital diseases. Date of publication 05/10/2005].
12. Krasochko, P.А. (2006). Ispol'zovanie probiotikov dlya profilaktiki zabolevanij zheludochno-kishechnogo trak-ta i terapii zhivotnyh [The use of probiotics for the prevention of diseases of the gastrointestinal tract and therapy of animals]. Utv. GUV MSKHP RB 21.06.2006 g. № 10-1-5/69. Izd. UO VGAVM [Approved. GUV MAKP RB 21.06.2006, No. 10-1-5 / 69. Ed. UO VGAVM]. Vitebsk, 86 p.
13. Krasochko, P.A. (2015). Instrukciya po primeneni-yu preparata «Laktimet» [Instructions for the use of the drug "Laktimet"]. Rassmotrena i odobrena na zasedanii Vetbio-farmsoveta Minsel'hozproda Respubliki Belarus', protokol № 77 ot 27 fevralya 2015 g [Considered and approved at a meeting of the Vetbiopharm Council of the Ministry of Agriculture of the Republic of Belarus, Protocol No. 77 of February 27, 2015]. Minsk: Nac. centr pravovoj inform. [Minsk: Nat. center of legal inform]. Rep. Belarus. 2 p.
14. Krasochko, P.A. (2016). [Instructions for the use of the probiotic drug "Batsinil"]. [Considered and approved at a meeting of the Vetbiopharm Council of the Ministry of Agriculture of the Republic of Belarus, Protocol No. 85 of July 15, 2016]. Minsk: Nac. centr pravovoj inform. [Minsk: Nat. center of legal inform]. Rep. Belarus, 3 p.
15. Kuvaeva, Z. (2009). Sovremennye lekarstvennye sredstva na osnove aminokislot [Modern medicines based on amino acids]. [Science and innovations] Minsk, no. 6(76), pp. 62–66.
16. Jason, C Siegler. (2015). Three and six grams supplementation of d-aspartic acid in resistance trained men Geoffrey W Melville. Journal of the International Society of Sports Nutrition. no. 3, pp. 18–19.
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