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Determination of parameters of acute toxicity of the new disinfectant " Dezsan"

At the present stage of the development of disinfectology to create a highly effective and absolutely safe for humans and animals disinfectants is impossible. Some medium that has a negative effect on a microorganism (slows down development or leads to its death) are dangerous for the whole biocenosis as a whole.

The article presents the results of studying the acute toxicity of the new disinfectant Dezsan for white mice.

Disinfectant Dezsan contains in its composition as active substances: alkyl dimethylbenzylammonium chloride, dedecyldimethylammonium chloride, glutaraldehyde and other auxiliary substances.

According to the nature of acute toxicity when injected into the stomach Glutaraldehyde belongs to the third grade of moderately hazardous substances. Glutaraldehyde has a pronounced local irritant effect on the skin and mucous membranes of the eye, possesses sensitizing properties. Alkyl dimethylbenzylammonium chloride and dedecyldimethylammonium chloride are quaternary salts and cationic active substances. Alkyl dimethylbenzylammonium chloride and dedecyldimethylammonium chloride exercise strong bactericidal, fungicidal, tuberculocidal, virulicidal action. Alkyl dimethylbenzylammonium chloride and dedecyldimethylammonium are used as disinfectant and raw materials in the production of disinfection and synthetic detergents for the dairy and meat industry. Alkyl dimethylbenzylammonium chloride and dedecyldimethylammonium belong to the 3 rd class of moderately hazardous substances when injected into the stomach. Ammonium groups CHAS form connections with carbonyl groups of glutaraldehyde and form highly effective complexes, thus creating a highly effective synergetic disinfection system that has all the benefits of active substances included in the composition. This composition has biocidal, antimicrobial properties for the entire spectrum of pathogenic microflora: bacteria, fungi and viruses.

The disinfectant Dezsan has toxic effect on the experimental animals at administration of a dose of 1200 cm3 / kg and above, with an interval of 100 cm3 / kg. In this case, the death of laboratory animals is observed in an amount from one head to five. As a result of the conducted studies it was established that the average dose of disinfectant Dezsan when introduced into the stomach by white mice is calculated by the methods of G. Kerber and G. Pershin is 1490 cm3 of the drug per 1 kg of animal mass. The parameters of the average dose of Dezsan for females of white mice with intragastric administration according to calculations by the method of B. Shtabsky is 1424.29 (1327.61 ÷ 1520.97) cm3 / kg of live weight.

Acute poisoning of laboratory animals was characterized by hyperemia and edema of the mucous membrane of the stomach and intestines, an increase in the spleen, congestion in the lungs, heart and liver.

According to sanitary-hygienic norms of GOST 12.1.007-76 in the toxicity class, the drug for desinfection Dezsan in a concentration of 2.5% when introduced into the stomach to white mice belongs to the fourth hazard class (low-risk compounds).

Key words: disinfectant Dezsan, acute toxicity, white mice, poisoning, hazard class.


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