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Diagnostic aspects of female pyometra (review information)

Pyometra is one of the most common and dangerous diseases in bitches, and its complicated course requires immediate treatment and, consequently, the need for highly informative, objective and reliable diagnostic approaches to recognition at the earliest possible stages of the disease. However, the complexity of the pathogenesis, staging and polysymptomatic pyometra cause certain problems in making the correct diagnosis and, consequently, the provision of adequate therapy. Despite the fact that today a number of methods for diagnosing pyometra in bitches have been proposed, none of them fully meets the needs of modern practical veterinary medicine. The purpose of the study was to conduct a systematic analysis and generalization of scientific publications on methods, criteria and approaches for the diagnosis of pyometra in bitches. Research methods such as search, selection, processing and analysis of literature sources in the field of research according to the rules for systematic reviews of the literature are used. Based on the analysis of data from selected articles, conclusions were made about the state of the chosen area of research – the effectiveness of methods, criteria and approaches for the diagnosis of pyometra in females. It is important in the diagnosis of pyometra to detect not only pathognomonic signs, but also early sepsis and the symptom complex of multiple organ failure. Therefore, the diagnosis of pyometra in bitches is made comprehensively, taking into account the anamnesis, clinical examination of animals, laboratory tests of blood and exudate. The standard package of diagnostic measures is based on the analysis of anamnesis data, determination of typical clinical signs, assessment of laboratory parameters and results of ultrasound examination. However, in practical veterinary medicine, the diagnosis of pyometra in bitches is usually made on the basis of anamnestic data and their revision, clinical examination and ultrasound diagnosis. When recognizing pyometra, it is necessary to keep in mind other possible causes of vaginal discharge and / or uterine enlargement, accompanied by a violation of the general condition of the animal, which should be considered as a differential diagnosis. Current research trends indicate promising development of biomarkers based on serum and endometrial transcripts for early diagnosis, prediction and differentiation of pyometra.

Key words: dogs, endometritis purulenta, methods, criteria and diagnostic approaches.

 

SKLYAROV P. https://orcid.org/0000-0002-4379-9583


PYATIBRAT V. https://orcid.org/0000-0002-1345-113X


  1. Allen, V.Je. (2002). Polnyj kurs akusherstva i ginekologii sobak [Complete course in obstetrics and gynecology of dogs]. Moscow: Akvarium, 448 p.
  2. Karpov, V.A. (1990). Akusherstvo i ginekologija melkih domashnih zhivotnyh [Small animal obstetrics and gynecology]. Moscow: Rosagropromizdat. 288 p.
  3. Kuz'mich, R.G., Mironchik, S.V., Golynec, V.G. (2012). Lechenie i profilaktika giperplasticheskoj patologii matki u suk: rekomendacii [Treatment and prevention of hyperplastic pathology of the uterus in bitches: recommendations]. Vitebsk: VGAVM, 46 p. Available at:www.vsavm.by/wp-content/uploads/2013/04/%D0%9A%D1%83%D0%B7%D1%8C%D0%BC%D... E%D0%BC%D0%B5%D0%BD%D0%B4%D0%B0%D1%86%D0%B8%D0%B8_%D1%81%D0%BE%D0%B1%D0 %B0%D0%BA%D0%B0.pdf.
  4. Djul'ger, G.P., Sibileva, Ju.G., Djul'ger, P.G., Hramcov, V.V., Leont'ev, L.B. (2019). Rasprostranenie, faktory riska, patofiziologija i sovremennye aspekty terapii piometry u sobak [Distribution, risk factors, pathophysiology and current aspects of pyometra therapy in dogs]. Izvestija Timirjazevskoj sel'skohozjajstvennoj akademii [News of the Timiryazev Agricultural Academy]. Issue 2, pp. 88–105. DOI: 10.34677/0021-342X-2019-2-88-105.
  5. Hagman, R. (2004). New aspects of canine pyometra – studies on epidemiology and pathogenesis: doctor’s dissertation: Veterinaria 182. Uppsala, 55 р. Available at: pub. epsilon.slu.se/736/1/Avhandlingsramen_f%C3%B6r_n%C3 %A4 rpublikation_R.Hagman.pdf.
  6. Marretta, S.M., Matthiesen, D.T., Nichols, R. (1989). Pyometra and its complications. Problems in veterinary medicine. Vol. 1 (1), pp. 50–62. PMID: 2520100.
  7. Jitpean, S., Ström–Holst, B., Emanuelson, U., Höglund, O.V., Pettersson, A., Alneryd–Bull, C., Hagman, R. (2014). Outcome of pyometra in female dogs and predictors of peritonitis and prolonged postoperative hospitalization in surgically treated cases. BMC veterinary research. Vol. 10, Issue 1, pp. 1–12. DOI:10.1186/ 1746-6148-10-6.
  8. Jitpean, S., Holst, B.S., Höglund, O.V., Pettersson, A., Olsson, U., Strage, E., Södersten, F., Hagman, R. (2014). Serum insulin-like growth factor-I, iron, C-reactive protein, and serum amyloid A for prediction of outcome in dogs with pyometra. Theriogenology. Vol. 82, Issue 1, pp. 43–48. DOI:10.1016/j. theriogenology.2014.02.014.
  9. Fransson, B.A., Karlstam, E., Bergstrom, A., Lagerstedt, A.S., Park, J.S., Evans, M.A., Ragle, C.A. (2004). C-reactive protein in the differentiation of pyometra from cystic endometrial hyperplasia/mucometra in dogs. J. Am. Anim. Hosp. Assoc., Vol. 40, Issue 5, pp. 391–399. PMID:15347619, DOI:10.5326/0400391.
  10. Wheaton, L.G., Johnson, A.L., Parker, A.J., Kneller, S.K. (1989). Results and complications of surgical treatment of pyometra: a review of 80 cases. J. Am. Anim. Hosp. Ass., Vol. 25, Issue 5, pp. 563–568. Available at: agris. fao.org/agris-search/search.do?recordID=US9017954.
  11. Rautela, R., Katiyar, R. (2019). Review on canine pyometra, oxidative stress and current trends in diagnostics. Asian Pacific Journal of Reproduction. Vol. 8, Issue 2, pp. 45–55. DOI:10.4103/2305-0500.254645.
  12. Omelianenko, M.M. (2004). Endometryt i piometra suk (kliniko-eksperymental'ni dani): avtoref. dys. ... kand. vet. nauk: 16.00.07. [Endometritis and pyometra of bitches (clinical and experimental data): the abstract of the dissertation of the candidate of veterinary sciences: 16.00.07.]. Kyiv, 20 p. Available at: www.irbis-nbuv.gov.ua/cgi-bin/irbis_nbuv/cgiirbis_64.exe?C21COM=2&I21DBN... ARD&IMAGE_FILE_DOWNLOAD=1&Z21ID=&Image_ file_name=DOC/2004/04ommked.zip.
  13. Boldarev, A.A. (2009). Diagnostika i organosohranjajushhaja terapija pri piometre u suk: avtoref. dis. ... kand. vet. nauk: 16.00.07. [Diagnosis and organpreserving therapy at a pyometra at bitches: the abstract of the dissertation of the candidate of veterinary sciences: 16.00.07.]. Voronezh, 23 p. Available at:www.dissercat.com/content/diagnostika-i-organosokhranyayushchaya-terapiy....
  14. Memon, M.A., Mickelsen, W.D. (1993). Diagnosis and treatment of closed–cervix pyometra in a bitch. Journal of the American Veterinary Medical Association. Vol. 203, Issue 4, pp. 509–512. PMID:8407505.
  15. Vandeplassche, M. (1991). Pyometra in the bitch: cytological, bacterial, histological, and endocrinological characteristics. Vlaams diergeneeskundig tijdschrift. Vol. 60, Issue 6, pp. 207–211. Available at:biblio.ugent.be/publication/226711.
  16. Stoilov, P.G., Lebedev, A.V., Stekol'nikov, A.A. (1996). Issledovanie matki u suk metodom ul'trazvukovogo skanirovanija [Study of the uterus in bitches by ultrasound scanning]. Nauchnye aspekty profilaktiki i terapii sel'skohozjajstvennyh zhivotnyh: mat. nauch. konf. [Scientific aspects of prevention and therapy of farm animals: proceedings of a scientific conference]. Voronezh, pp. 121–120.
  17. Shafikova, A.V. (2006). Jetiologija, diagnostika i lechenie pri jendometritah u sobak: dis. ... kand. vet. nauk: 16.00.07 [Etiology, diagnosis and treatment of endometritis in dogs: Ph.D. thesis: 16.00.07]. Persianovsky, 152 p. Available at: www.dslib.net/vet-akusherstvo/jetiologija-diagnostika-ilechenie-pri-jendometritah-u-sobak.html.
  18. England, G.C., Heimendahl, A.V. (Ed.). (2010). BSAVA manual of canine and feline reproduction and neonatology. British Small Animal Veterinary Association, 230 p. DOI:10.22233/9781905319541.ind.
  19. Simpson, Dzh., Ingland, G., Harvi, M. (2005). Rukovodstvo po reprodukcii i neonatologii sobak i koshek [Canine and Feline Reproduction and Neonatology Guide]. Moscow: Sofion, 280 p. DOI:10/07/2010 20:04.
  20. Ovcharuk, N.P., Kravchuk, O.O. (2016). Diahnostyka ta problema likuvannia piometry u domashnikh sobak (zarubizhnyi ta vitchyznianyi dosvid) [Diagnosis and treatment of pyometra in domestic dogs (foreign and domestic experience)]. Molodyi vchenyi [A young scientist]. no. 2 (29), pp. 173–177. Available at:irbis-nbuv.gov.ua/cgi-bin/irbis_nbuv/cgiirbis_64.exe?C21COM=2&I21DBN=UJRN&P21DBN=UJRN&IMAGE_ FILE_DOWNLOAD=1&Image_file_name=PDF/ molv_2016_2_44.pdf.
  21. Chunosova, S.A., Filippova, O.V., Sorokin, V.I. (2011). Ul'trazvukovaja diagnostika patologij matki u suk [Ultrasound diagnostics of uterine pathologies in bitches]. Izvestija Orenburgskogo gosudarstvennogo agrarnogo universiteta [Bulletin of the Orenburg State Agrarian University]. Vol. 4, no. 32–1, pp. 141–144. Available at:cyberleninka.ru/article/n/ultrazvukovaya-diagnostikapatologiy-matki-u-suk.
  22. Kartashov, S.N. (2005). Metropatii sobak: diagnostika, klassifikacija, lechenie: avtoref. dis. ... dokt. biol. nauk: 16.00.02, 16.00.07 [Metropathies of dogs: diagnosis, classification, treatment: abstract of doctoral dissertation: 16.00.02, 16.00.07]. Stavropol, 43 p. Available at:new-disser.ru/_avtoreferats/ 01003013013.pdf.
  23. Al'djakov, A.V., Nazarov, S.D. (2018). Diagnostika i lechenie piometry u sobak [Diagnosis and treatment of pyometra in dogs]. Razvitie agrarnoj nauki kak vazhnejshee uslovie jeffektivnogo funkcionirovanija agropromyshlennogo kompleksa strany: sb. mat. Vseros. nauch.-prakt. konf. [The development of agrarian science as the most important condition for the effective functioning of the country's agroindustrial complex: collection of materials of the All–Russian scientific and practical conference]. pp. 113–116. Available at: academy21.ru/engine/download. php?id=14825.
  24. Privalihina, A.A., Badova, O.V. (2019). Sovremennye metody diagnostiki i lechenija piometry u sobak [Modern methods of diagnosis and treatment of pyometra in dogs]. Molodezh' i nauka [Youth and Science]. no. 2, 33 p. Available at: min.usaca.ru/issues/72/articles/4269.
  25. Shevko, D.O., Hotmirova, O.V. (2018). Diagnostika i lechenie piometry u sobaki [Diagnosis and treatment of pyometra in a dog]. Nauchnye problemy proizvodstva produkcii zhivotnovodstva i uluchshenija ee kachestva: mat. nauch.-prakt. konf. studentov i aspirantov [Scientific problems of livestock production and improving its quality: materials of the scientific and practical conference of students and postgraduates]. pp. 120–123. Available at: elibrary. ru/ item.asp?id=36840283.
  26. Astrjanskaja, O.V. (2013). Kliniko-morfologicheskie kriterii diagnostiki i terapii jendometropatii: avtoref. dis. ... kand. vet. nauk: 06.02.06 [Clinical and morphological criteria for the diagnosis and therapy of endometropathy: Ph.D. thesis abstract: 06.02.06.]. Saratov, 17 p. Available at:en.sgau.ru/ files/pages/3546/13851219660.pdf.
  27. Zöldag, L., Vöros, K., Benedek, D., Vrabely, T. (1992). The diagnostic value of sonography in the clinical picture of pyometra in the dog. Tierarztliche Praxis. Vol. 20, Issue 5, pp. 523–529. PMID:1440600.
  28. Santana, C.H., Santos, R.L. (2021). Canine pyometra – an update and revision of diagnostic terminology. Brazilian Journal of Veterinary Pathology. Vol. 14, Issue 1, pp. 1–8. DOI:10.24070/bjvp.1983-0246.v14i1p1-8.
  29. Shahov, P.A., Gorelikov, F.V. (2013). Primenenie gamavita pri lechenii piometry u sobak [The use of gamavit in the treatment of pyometra in dogs]. Naukovi pratsi Pivdennoho filialu Natsionalnoho universytetu bioresursiv i pryrodokorystuvannia Ukrainy «Krymskyi ahrotekhnolohichnyi universytet» [Scientific works of the Southern branch of the National University of Life and Environmental Sciences of Ukraine "Crimean Agrotechnological University"]. Issue 155, pp. 292–297. Available at: nbuv.gov.ua/UJRN/Npkau_2013_155_53.
  30. Zueva, N.M. (2003). Morfofunkcional'noe obosnovanie ul'trazvukovogo metoda diagnostiki sostojanij organov reproduktivnoj sistemy u samok sobak: avtoref. dis. ... kand. biol. nauk: 16.00.02 [Morphological and functional substantiation of the ultrasound method for diagnosing the states of the organs of the reproductive system in female dogs: abstract of the candidate's dissertation: 16.00.02.]. Moscow, 16 p. Available at:www.dissercat.com/content/morfofunktsionalnoe-obosnovanie-ultrazvukovogo....
  31. De Schepper, J., Van der Stock, E. Capiau, J. (1987). The characteristic pattern of aspartate aminotransferase and alanine aminotransferase in the bitch with the cystic hyperplasiapyometra complex: effect of medical or surgical treatment. Vet. Res. Com. Vol. 11, pp. 65–75. DOI:10.1007/ bf00361327.
  32. Volkov, P.A. (2005). Postroenie i ispol'zovanie indeksov tjazhesti pri diagnostike i lechenii piometry u suk: avtoref. dis. ... kand. vet. nauk: 16.00.07 [Construction and use of severity indices in the diagnosis and treatment of pyometra in bitches: author's abstract of the candidate's dissertation: 16.00.07.]. Voronezh, 24 p. Available at:medical-diss.com/ docreader/129827/a ?#?page=1.
  33. Ros, L., Holst, B.S., Hagman, R. (2014). A retrospective study of bitches with pyometra, medically treated with aglepristone. Theriogenology. Vol. 82, pp. 1281–1286. PMID:25234791, DOI:10.1016/j.theriogenology.2014.08.011.
  34. Verstegen, J., Dhaliwal, G., Verstegen-Onclin, K. (2008). Mucometra, cystic endometrial hyperplasia, and pyometra in the bitch: Advances in treatment and assessment of future reproductive success. Theriogenology. Vol. 70, Issue 3, pp. 364–374. PMID:18501959, DOI:10.1016/j. theriogenology.2008.04.036.
  35. Martynova, Ju.S., Martynov, A.N., Turkov, V.G., Kletikova, L.V. (2015). Rol' belkov ostroj fazy vospalenija v patogeneze piometry [The role of proteins in the acute phase of inflammation in the pathogenesis of pyometra]. Uchenye zapiski Kazanskoj gosudarstvennoj akademii veterinarnoj mediciny im. N.Je. Baumana [Scientific notes of the Kazan State Academy of Veterinary Medicine named after N.E. Bauman]. Vol. 221 (1), pp. 144–146. Available at: cyberleninka.ru/article/n/rol-belkov-ostroy-fazyvospaleniya-v-patogeneze-piometry.
  36. Porowska, E., Kulus, M., Jankowski, M., Kocherova, I., Jeseta, M., Chamier–Gliszczyńska, A., Stefańska, K., Borowiec, B., Bukowska, D., Brüssow, K.P., Kempisty, B., Antosik, P. (2018). Selected aspects of endometritis – pyometra complex in dogs – current troubles and treatment perspectives. Medical Journal of Cell Biologyno. no. 6 (3), pp. 108–113. DOI:10.2478/acb-2018- 0017.
  37. Hardy, R.M., Osborne, C.A. (1974). Canine pyometra: pathophysiology, diagnosis and treatment of uterine and extra-uterine lesions. J. Am. Anim. Hosp. Assoc. Vol. 10, Issue 3, pp. 245–268. Available at: agris.fao.org/ agris-search/search. do?recordID=US201303170242.
  38. Hagman, R. (2017). Canine pyometra: What is new? Reproduction in domestic animals. Vol. 52, pp. 288– 292. PMID:27807901, DOI:10.1111/rda.12843.
  39. Singh, L.K., Patra, M.K., Mishra, G.K., Saxena, A.C., De, U.K., Singh, S.K., Kumar, H., Narayanan, K. (2020). Prospects of diagnostic and prognostic biomarkers of pyometra in canine. Asian Pacific Journal of Reproduction. Vol. 9, Issue 4, pp. 166–173. DOI:10.4103/2305-0500.288584.
  40. Renton, J.P., Boyd, J.S., Harvey, M.J. (1993). Observations on the treatment and diagnosis of open pyometra in the bitch (Canis familiaris). J. Reprod. Fert. Vol. 47, pp. 465–469. PMID:8229963.
  41. Fransson, B.A., Ragle, C.A. (2003). Canine pyometra: An update on pathogenesis and treatment. Comp. Cont. Educ. Pract. Vet. Vol. 25, pp. 602–612. Available at: eurekamag.com/research/003/668/003668354.php.
  42. Boldarev, A.A. (2019). Differencial'nodiagnosticheskie rentgenologicheskie priznaki metropatij u suk pri raznyh formah klinicheskogo techenija [Differential diagnostic radiological signs of metropathy in bitches with different forms of clinical course]. Izvestija Nizhnevolzhskogo agrouniversitetskogo kompleksa: nauka i vysshee professional'noe obrazovanie [Bulletin of the Nizhnevolzhsky agrouniversity complex: science and higher professional education]. no. 1 (53), pp. 182–188. Available at:cyberleninka.ru/article/n/differentsialno-diagnosticheskierentgenolo gicheskie-priznaki-metropatiy-u-suk-pri-raznyhformah-klinicheskogo-techeniya.
  43. Baltuhaeva, T.A., Mel'cov, I.V., Hazhinova, A.V. (2014). Morfobiohimicheskie pokazateli krovi u sobak pri piometre [Morphobiochemical parameters of blood in dogs with pyometra]. Fundamental'nye i prikladnye issledovanija v veterinarii i biotehnologii [Basic and applied research in veterinary medicine and biotechnology]. pp. 18–23. Available at:elibrary.ru/item.asp? id=30471269.
  44. Shevchenko, S.I., Kanunnikova, A.G., Zhilinkova, O.Ju. (2018). Differencial'naja diagnostika piometry i jendometrita u sobak pri pomoshhi sonografii [Differential diagnosis of pyometra and endometritis in dogs using sonography]. Nauchnoe soobshhestvo studentov. Mezhdisciplinarnye issledovanija: stud. zaochnaja mezhdunar. nauch.-prakt. konf. [Scientific community of students. Interdisciplinary research: student correspondence international scientific and practical conference]. рр. 130– 134. Available at:elibrary.ru/item.asp?id=35336058.
  45. Karlsson, I., Hagman, R., Johannisson, A., Wang, L., Karlstam, E., Wernersson, S. (2012). Cytokines as immunological markers for systemic inflammation in dogs with pyometra. Reproduction in domestic animals. Vol. 47, Suppl. 6, pp. 337–341. PMID:23279533, DOI:10.1111/ rda.12034.
  46. Kaymaz, M., Baştan, A., Erünal, N., Aslan, S., Findik, M. (1999). The use of laboratory findings in the diagnosis of CEH-pyometra complex in the bitch. Turkish Journal of Veterinary and Animal Sciences. Vol. 23, Issue 2, pp. 127–134. Available at:journals.tubitak.gov.tr/veterinary/ issues/vet-99-23-2/vet-23-2-5-97158.pdf.
  47. Tecles, F., Escribano, D., Contreras–Aguilar, M.D., Rubio, C.P., Szczubiał, M., Cerón, J.J., Dąbrowski, R.,, Tvarijonaviciute A. (2018). Evaluation of adenosine deaminase in saliva and serum, and salivary α-amylase, in canine pyometra at diagnosis and after ovariohysterectomy. The Veterinary Journal. Vol. 236, pp. 102–110. DOI:10.1016/j. tvjl.2018.04.018.
  48. Fayrer–Hosken, R.A., Mahaffey, M., Miller– Liebl, D., Candle, A.B. (1991). Early diagnosis of canine pyometra using ultrasonography. Vet. Radiol. Vol. 32, pp. 287–289. DOI:10. 1111/j.1740-8261.1991.tb00125.x.
  49. Gupta, S., Rajiah, P., Middlebrooks, E.H., Baruah, D., Carter, B.W., Burton, K.R., Chatterjee, A.R., Miller, M.M. (2018). Systematic review of the literature: best practices. Academic radiology. Vol. 25, Issue 11, pp. 1481– 1490. PMID:30442379, DOI:10.1016/j.acra.2018.04.025.
  50. Hagman, R. (2018). Pyometra in small animals. Veterinary clinics of North America. Small Animal Practice. Vol. 48, Issue 4, pp. 639–661. PMID:29933767, DOI:10.1016/j.cvsm. 2018.03.001.
  51. Smith, F. (2006). Canine pyometra. Theriogenology. Vol. 66, pp. 610–612. PMID:16828 152, DOI:10.1016/j. Theriogenology.2006.04.023.
  52. Feldman, E.C., Nelson, R.W. (2004). Canine and feline endocrinology and reproduction (3rd ed.). USA: Elsevier, 1089 p.
  53. Kempisty, B., Bukowska, D., Wozna, M., Piotrowska, H., Jackowska, M., Zuraw, A., Ciesiolka, S., Antosik, P., Maryniak, H., Ociepa, E., Porowski, Sz., Brussow, K.P., Jaskowski, J.M., Nowicki, M. (2013). Endometritis and pyometra in bitches: A review. Vet. Med. Vol. 58, pp. 289–297. DOI:10.17221/6864-vetmed.
  54. Fransson, B., Lagerstedt, A.S., Jonsson, P. (1997). Bacteriological findings, blood chemistry profile and plasma endotoxin levels in bitches with pyometra or other uterine disease. J. Vet. Med. Physiol. Pathol. Clin. Med. Vol. 44, pp. 417–426. DOI:10.1111/j.1439-0442.1997. tb01127.x.
  55. Djul'ger, G.P., Djul'ger, P.G. (2018). Fiziologija razmnozhenija i reproduktivnaja patologija sobak [Reproductive physiology and reproductive pathology of dogs]. St. Petersburg: Lan, 236 p.
  56. De Schepper, J., Van der Stock, J., Capiau, E. (1986). The morphological and biochemical blood profile in different forms of endometritis post oestrum (pyometra) in the dog. A study of 96 cases. Vlaams Diergen Tijds. Vol. 55, pp. 153–162. Available at:eurekamag. com/ research/001/412/001412191.php.
  57. Jitpean, S., Ambrosen, A., Emanuelson, U., Hagman, R. (2016). Closed cervix is associated with more severe illness in dogs with pyometra. BMC veterinary research. Vol. 13 (1), pp. 1–7. DOI:10.1186/s12917-016-0924-0.
  58. Walker, R.G. (1965). The diagnosis of “open” and “closed” pyometra in the dog and cat - II: diagnosis and assessment of closed pyometritis in the bitch. J. Small Anim. Pract. Vol. 6, pp. 437–444. DOI:10.1111/j.1748-5827.1965. tb04361.x.
  59. Robaj, A., Sylejmani, D., Hamidi, A. (2018). Occurrence and antimicrobial susceptibility of bacterial agents of canine pyometra. Indian Journal of Animal Research. no. 52 (3), pp. 397–400. DOI:10.18805/ijar. v0iof.6830.
  60. Singh, L.K., Patra, M.K., Mishra, G.K., Singh, V., Upmanyu, V., Saxena,A.C., Singh, S.K., Das, G.K., Kumar, H., Krishnaswamy, N. (2018). Endometrial transcripts of proinflammatory cytokine and enzymes in prostaglandin synthesis are upregulated in the bitches with atrophic pyometra. Veterinary Immunology and Immunopathology. no. 205, pp. 65–71. PMID:30459003, DOI:10. 1016/j. vetimm.2018.10.010.
  61. Dhaliwal, G.K., Wray, C., Noakes, D.E. (1998). Uterine bacterial flora and uterine lesions in bitches with cystic endometrial hyperplasia (pyometra). Vet. Rec. Vol. 143, pp. 659–661. PMID:9885130, DOI:10.1136/vr.143.24.659.
  62. Fransson, B. (2003). Systemic inflammatory response in canine pyometra: the response to bacterial uterine infection: doctoral thesis (veterinaria) Swedish University of Agricultural Sciences. Uppsala, 49 p. Available at:citeseerx. ist.psu.edu/viewdoc/download?doi=10.1.1.629.5368&rep=r ep 1&type=pdf.
  63. Jitpean, S. (2015). Predictive markers and risk factors in canine pyometra: doctoral thesis Swedish University of Agricultural Sciences. Uppsala, 73 p. Available at:pub.epsilon.slu.se/12581/ 1/jitpean_s_150903.pdf.
  64. Kitshoff, A.M., van Goethem, B., Boyen, F., Tas, O. Polis, I., de Rooster H. (2015). Clinical parameters as predictors of bacterial isolation in the uterine content of dogs suspected of pyometra. Vlaams Diergen Tijds. Vol. 84, pp. 188–196. DOI:10.21825/vdt.v84i4.16594.
  65. Nomura, K., Yoshida, K., Funahashi, H., Shimada, Y. (1988). The possibilities of uterine invasion of Escherichia coli inoculated into the vagina and development of endometritis in the bitches. Jpn. J. Anim Reprod. Vol. 34, pp. 199–203. DOI:10.1262/jrd1977.34.199.
  66. Sevelius, E., Tidholm, A., Thoren, T.K. (1990). Pyometra in the dog. J. Am. Anim. Hosp. Ass. Vol. 26, pp. 33–38. Available at:cabdirect.org/cabdirect/ abstract/19902212398.
  67. Kudrjavcev, A.A., Kudrjavceva, L.A. (1974). Klinicheskaja gematologija zhivotnyh [Clinical hematology of animals]. Moscow: Kolos, 399 p.
  68. Kulakov, V.I., Serov, V.N., Abubakirova, A.N., Chernuha, E.A., Baranov, I.I., Fedorova, T.A. (2000). Anestezija i reanimacija v akusherstve i ginekologii [Anesthesia and resuscitation in obstetrics and gynecology]. Moscow: Triada X, 382 p.
  69. Zhmakin K.N. (Ed.) (1986). Osnovy jendokrinologicheskoj ginekologii [Fundamentals of Endocrinological Gynecology]. Moscow: Medicina, 376 p.
  70. Sol'skij, Ja.P. (1977). Prakticheskoe akusherstvo [Practical obstetrics]. Kyiv: Health, 663 p.
  71. Shah, S.A., Sood, N.K., Wani, B.M., Rather, M.A., Beigh, A.B., Amin, U. (2017). Haemato-biochemical studies in canine pyometra. Journal of Pharmacognosy and Phytochemistry. Vol. 6, Issue 4, pp. 14–17. Available at:researchgate.net/publication/323958412_Haemato-bioche mical_studies_in_canine_pyometra.
  72. Maddens, B., Heiene, R., Smets, P., Svensson, M., Aresu, L., Van der Lugt, J., Daminet, S., Meyer, E. (2011). Evaluation of kidney injury in dogs with pyometra based on proteinuria, renal histomorphology, and urinary biomarkers. J. Vet. Intern. Med. Vol. 25, Issue 5, pp. 1075–1083. PMID:21848947, DOI:10.1111/j.1939-1676.2011.0772.x.
  73. Tvedten, H. (1989). Erythrocyte disorders and leukocyte disorders. Philadelphia WB Saunders, pp. 36–85.
  74. Hagman, R., Lagerstedt, A.S., Hedhammar, A., Egenvall, Å. (2011). A breed-matched case-control study of potential risk-factors for canine pyometra. Theriogenology. Vol. 75, Issue 7, pp. 1251–1257. PMID: 21196041, DOI:10.1016/j.theriogenology.2010.11.038.
  75. Gandotra, V.K., Singla, V.K., Kochhar, H.P.S., Chauhan, F.S., Dwivedi, P.N. (1994). Haematological and bacteriological studies in canine pyometra. Indian Vet. J. Vol. 71, pp. 816–818.
  76. Bigliardi, E., Parmigiani, E., Cavirani, S., Luppi, A., Bonati, L., Corradi, A. (2004). Ultrasonography and cystic endometrial hyperplasia – pyometra complex in the bitch. Reproduction in Domestic Animals. Vol. 39, pp. 136–140. PMID:15182288, DOI:10.1111/j.1439-0531.2004. 00489.x.
  77. Emel'janova, H.S. (2006). Klinicheskie i mikrobiologicheskie aspekty jendometrita domashnih plotojadnyh [Clinical and microbiological aspects of endometritis in domestic carnivores]. Aktual'nye problemy veterinarnoj mediciny: mat. vet. konf. [Actual problems of veterinary medicine: materials of the veterinary conference]. Novosibirsk, pp. 15–17. Available at:nsau.edu.ru/images/ vetfac/images/ ebooks/pages/2006/1/Emeljanova.htm.
  78. Il'chenko, L.S., Mironova, L.P., Oblap, O.M. (2020). Nekotorye osobennosti gematologicheskogo issledovanija sobak s diagnozom pyometra [Some features of hematological examination of dogs diagnosed with pyometra]. Aktual'nye voprosy diagnostiki, lechenija i profilaktiki boleznej zhivotnyh i ptic: mat. Mezhdunar. nauch.-prakt. konf. [Topical issues of diagnosis, treatment and prevention of diseases of animals and birds: materials of the International Scientific and Practical Conference. Persianovsky]. Persianovsky, pp. 88–92. Available at:elibrary. ru/item.asp?id=44147552.
  79. Patil, A.R., Swamy, M., Chandra, A., Jawre, S. (2013). Clinico-haematological and serum biochemical alterations in pyometra affected bitches. African Journal of Biotechnology. Vol. 12, no. 13, pp. 1564–1570. DOI:10.5897/ AJB12.2510.
  80. De Schepper, J., Van Der Stock, J., Capiau, E. (1987). Anaemia and leycocytosis in one hundred and twelve dogs with pyometra. Small anim. Preat. Vol. 28, Issue 2, pp. 187–195. DOI:10.1111/j.1748-5827.1987.tb05978.x.
  81. Stone, E.A., Littman, M.P., Robertson, J.L., Bovee, K.C. (1988). Renal dysfunction in dogs with pyometra. J. Am. Vet. Med. Ass. Vol. 193, pp. 457–464. PMID:3170321.
  82. Nelson, R.W., Feldman, E.C. (1986). Pyometra. Veterinary clinics of North America: Small animal practice. Vol. 16, Issue 3, pp. 561–576. DOI:10.1016/S0195- 5616(86)50061-9.
  83. Kuznecova, T.Sh. (2010). Harakteristika funkcional'nogo sostojanija pecheni u sobak, bol'nyh piometroj [Characteristics of the functional state of the liver in dogs with pyometra]. Veterinarnaja medicina [Veterinary medicine]. no. 1, pp. 38–39. URL:ветмед.рф/num1-2010.pdf#page=36.
  84. Dabrowski, R., Kostro, K., Szczubial, M. (2013). Concentrations of C-reactive protein, serum amyloid A, and haptoglobin in uterine arterial and peripheral blood in bitches with pyometra. Theriogenology. Vol. 80, pp. 494–497. PMID:23810209, DOI:10.1016/j.theriogenology.2013.05. 012.
  85. Yoon, J.S., Yu, D., Park, J. (2021). Changes in the serum protein electrophoresis profile in dogs with pyometra. Frontiers in Veterinary Science. Vol. 8, 133 p. PMID:33732740, PMCID:P MC7956968, DOI:10.3389/ fvets.2021.626540.
  86. Woźna–Wysock, M., Rybska, M., Błaszak, B., Jaśkowski, B.M., Kulus, M., Jaśkowski, J.M. (2021). Morphological changes in bitches endometrium affected by cystic endometrial hyperplasia–pyometra complex – the value of histopathological examination. BMC Veterinary Research. Vol. 17, Issue 1, pp. 1–11. PMID:33902588, PMCID:PMC8077759, DOI:10.1186/s129 17-021-02875-0.
  87. Medvedev M.A. (2008). Klinicheskaja veterinarnaja laboratornaja diagnostika [Medvedev M.A. Clinical veterinary laboratory diagnostics]. Moscow: Akvarium-Print, 416 p.
  88. Jarilin, A.A. (1999). Osnovy immunologii [Fundamentals of Immunology]. Moscow: Medicine, 608 p.
  89. Shevchenko, O.P. (2005). Harakteristika i klinicheskoe znachenie belkov ostroj fazy vospalenija [Characteristics and clinical significance of proteins in the acute phase of inflammation]. V kn.: Laboratornaja diagnostika (red. V.V. Dolgov, O.P. Shevchenko) [In: Laboratory diagnostics (ed. V.V. Dolgov, O.P. Shevchenko).]. Moscow: Reafarm, pp. 137–143.
  90. Arteaga, A., Dhand, N.K., Mcсann, T., Knottenbelt, C.M., Tebb, A.J. (2010). Kontrol' jeffektivnosti terapii giperadrenokorticizma sobak trilostanom po koncentracii belkov ostroj fazy [Monitoring the effectiveness of therapy for hyperadrenocorticism in dogs with trilostane by the concentration of acute phase proteins]. Jsap (Russian Edition). Vol. 1, no. 2, pp. 5–11. Available at: cyberleninka.ru/article/n/ kontrol-effektivnosti-terapii-giperadrenokortitsizma-sobaktrilostanom-po-kontsentratsii-belkov-ostroy-fazy.
  91. Bree, H.V., Schepper, J.D., Capiau, E. (1988). The significance of radiology in the diagnosis of pyometra (endometritis post oestrum) in dogs: An evaluation of the correlation between radiographic and laboratory findings in 131 cases. Journal of Veterinary Medicine series A. Vol. 35, Issue 1–10, pp. 200–206. PMID:3133907, DOI:10.1111/j.1439-0442.1988.tb00023.x.
  92. Mattei, C., Fabbi, M., Hansson, K. (2018). Radiographic and ultrasonographic findings in a dog with emphysematous pyometra. Acta Veterinaria Scandinavica. Vol. 60, Issue 1, pp. 115–118. PMID: 30373618, PMCID: PMC6206667, DOI:10.1186/s13028-018-0419-z.
  93. Yun, S., Lee, J., Choi, M., Yoon, J. (2017). Radiographic uterine diameter evaluation for the detection of uterine disease in dogs: A retrospective study. Journal of Veterinary Clinics. no. 34 (6), pp. 420–424. DOI:10.17555/ jvc.2017.12.34.6.420.
  94. Root, C.N. (1974). Interpretation of abdominal survey radiographs. Vet. Clin. North. Am. Vol. 4, pp. 763–803. PMID:4373896, DOI:10.1016/s0091-0279 (74) 50084-x.
  95. Shull, R.M., Johnston, S.D., Johnston, G.R., Caywood, D., Stevens, J.B. (1978). Bilateral torsion of uterine horns in a non–gravid bitch. J. Am. Vet. Med. Assoc. Vol. 172, pp. 601–603. PMID:632203.
  96. Sokolovskij, R.M. (1977). Morfogenez i patogenez «psevdojerozii» shejki matki zhenshhiny: avtoref. dis. d-ra. med. nauk [Morphogenesis and pathogenesis of "pseudoerosion" of the woman's cervix: abstract of dissertation and doctor of medical sciences]. Leningrad, 25 p.
  97. Topchieva, O.I. (1983). Vlijanie jestrogennyh gormonov na techenie vospalitel'nogo i regenerativnogo processa v jendometrii [Influence of estrogenic hormones on the course of the inflammatory and regenerative process in the endometrium]. Akusherstvo i ginekologija [Obstetrics and gynecology]. no. 6, pp. 79–84.
  98. Wessels, B.C., Wessels, M.T. (1989). Antiendotoxin immunotherapy for canine pyometra endotoxemia. The Journal of the American Animal Hospital Association. Vol. 25, Issue 4, pp. 455–460. Available at:agris.fao.org/agrissearch/ search.do?recordID=US19900008589.
  99. Barr, F. (2006). Ul'trazvukovaja diagnostika zabolevanij sobak i koshek [Ultrasound diagnostics of diseases of dogs and cats]. Moscow: Akvarium-Print, 208 p.
  100. Moldabaeva, A.Zh., Orynhanov, K.A., Kojbagarov, K.U., Abdulla, A.A., Hasanova, G.A. (2019). Rezul'taty klinicheskih issledovanij i ul'trazvukovoj dіagnostiki piometry u sobak [Results of clinical studies and ultrasound diagnostics of pyometra in dogs]. Agrarnaja nauka – sel'skomu hozjajstvu: mat. Mezhdunar. nauch.-prakt. konf. [Agricultural science - agriculture: materials of the international scientific and practical conference]. Barnaul, pp. 321–324. URL:elibrary. ru/item.asp?id=41259467.
  101. Voges, A.K., Neuwirth, L. (1996). Ultrasound diagnosis-cystic uterine hyperplasia. Vet. Radiol. Ultrasound. Vol. 37, pp. 131–132. DOI:10.1111/j.1740-8261.1996. tb01210.x.
  102. Nyland, T.G., Mattoon, J.S. (2014). Small animal diagnostic ultrasound (3nd ed.). USA: Saunders, 680 p.
  103. Pretzer, S.D. (2008). Clinical presentation of canine pyometra and mucometra: a review. Theriogenology. Vol. 70, Issue 3, pp. 359–363. PMID:18513791, DOI:10.1016/j. therioge nology.2008.04.028.
  104. Batista, P.R., Gobello, C., Rube, A., Corrada, Y.A., Tórtora, M., Blanco, P.G. (2016). Uterine blood flow evaluation in bitches suffering from cystic endometrial hyperplasia (CEH) and CEH-pyometra complex. Theriogenology. Vol. 85, pp. 1258–1261. PMID:26810829, DOI:10. 1016/j.theriogenology. 2015.12.008.
  105. Vermeirsch, H., Simoens, P., Lauwers, H., Coryn, M. (1999). Immunohistochemical detection of estrogen receptors in the canine uterus and their relation to sex steroid hormone levels. Theriogenology. Vol. 51, pp. 729–743. PMID:10728998, DOI:10.1016/s0093-691x(99)00022-9.
  106. Groppetti, D., Pecile, A., Arrighi, S., Giancamillo, D., Cremonesi, F. (2010). Endometrial cytology and computerized morphometric analysis of epithelial nuclei: A useful tool for reproductive diagnosis in the bitch. Theriogenology. Vol. 73, pp. 927–941. PMID:20116837, DOI:10.1016/j.theriogenology.2009.11.019.
  107. Hagman, R., Kindahl, H., Fransson, B.A., Bergström, A., Holst, B.S., Lagerstedt, A.S. (2006). Differentiation between pyometra and cystic endometrial hyperplasia/mucometra in bitches by prostaglandin F2α metabolite analysis. Theriogenology. Vol. 66, Issue 2, pp. 198–206. PMID:16375957, DOI:10.1016/j. theriogenology.2005.11.002.
  108. Sant’Anna, M.C., Giordano, L.G.P., Flaiban, K.K.M.C., Muller, E.E., Martins, M.I.M. (2014). Prognostic markers of canine pyometra. Arq. Bras. Med. Vet. Zootec. Vol. 66, Issue 6, pp. 1711–1717. DOI:10.1590/1678-6859.
  109. Hauptman, J.V. Walshaw, R., Olivier, N.B. (1997). Evaluation of the sensitivity and specificity of diagnostic criteria for sepsis in dogs. Vet. Surg. Vol. 26, pp. 393–397. PMID:938 1665, DOI:10.1111/j.1532-950x.1997.tb01699.x.
  110. Kuznecova, T.Sh. (2013). Morfologicheskie i funkcional'nye izmenenija pri ovariogisterojektomii u sobak s piometroj: avtoref. dis. ... kand. biol. nauk: 06.02.01 [Morphological and functional changes during ovariohysterectomy in dogs with pyometra: abstract of the candidate of biological sciences: 06.02.01.]. Moscow, 18 p. Available at:earthpapers.net/ preview/448288/a#?page=1.
  111. Nimand, H.G., Suter, P.F. Bolezni sobak. (2001). Prakticheskoe rukovodstvo dlja veterinarnyh vrachej (organizacija veterinarnoj kliniki, obsledovanie, diagnostika zabolevanij, lechenie) [A practical guide for veterinarians (organization of a veterinary clinic, examination, diagnosis of diseases, treatment)]. Moscow: AQUARIUM LTD, 816 p.
  112. Farrou, S.S. (1996). Rentgenogrammy, special'no prednaznachennye dlja postanovki diagnoza u bol'noj sobaki [Radiographs specifically designed for diagnosis in a sick dog]. Focus. Vol. 6, no. 4, pp. 25–28. Available at: www. dompitomci.ru/doc/vet/vet_doc/vf64/rent.html.
  113. Berezovskyi, A.V., Kharenko, M.I. (Red.) (2017). Fiziolohiia ta patolohiia rozmnozhennia dribnykh tvaryn (2-e vyd., pererob. i dop.) [Physiology and pathology of reproduction of small animals (2nd ed., Processing and add.)]. Zhytomyr: Polissya, 392 p.
  114. Martynova, Ju.S., Martynov, A.N., Turkov, V.G., Kletikova, L.V., Shumakov, V.V., Jakimenko, N.N., Kokurin, V.N., Bekasheva, I.V. (2015). Opyt ispol'zovanija aglepristona i kloprostenola pri piometre u suki [Experience of using aglepristone and cloprostenol for pyometra in a bitch]. Sovremennye problemy nauki i obrazovanija [Modern problems of science and education]. no. 1–1. Available at:science-education.ru/ru/article/view?id=18795.
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