You are here
Hemocytopoiesis and microelements metabolism’s indices in calves under the infl uence of national vitamin-amino-acid complex
In Ukrainian veterinary medicine the study of the eff ectiveness of new complex drugs remains relevant. The eff ect of the vitamin-mineral complex "Alphabet for Animals" on the state of hemocytopoiesis and the microelements metabolism in calves of 1.5‒2.5 months of age were studied. The composition of this drug includes the biologically active substances: vitamins A, D3, E, B1, B3, B5, B6, B12, K3 and essential amino-acids: DL-methionine, L-lysine and arginine. It is used in farm animals and poultry for the normalization of hemocytopoiesis, the prevention and treatment of vitamins and trace elements metabolism’s disorders. In the fi rst week of drug administration, the number of erythrocytes in the experimental animals group has increased signifi cantly (p<0.05) and after its second feeding, the positive eff ect on erythrocytopoiesis in calves has became even greater (p<0.001), compared to the calves in control group. The level of hemoglobin in calves of experimental group also increased signifi cantly from the beginning of the drug to the end of the experiment, whereas in calves of the control group there was a tendency to decrease its level throughout the all experiment. The color index and erythrocyte saturation by hemoglobin (MCH) at the fi rst and second blood samples were signifi cantly decreased (p<0.05) in control calves group, whereas in animals of experimental group there was no signifi cant diff erence between these parameters (p<0.1). The average volume of red blood cells did not diff er between control and test calves during the experiment (р<0.1). Under the drugs infl uence the Ferum blood content in calves of experimental group increased by 24.2 %. In the control calves group, this tendency was not so noticeable (the increase of Ferum serum level at the end of experiment was only +7.8 % (p<0.1), compared to the initial indices). The Zinc metabolism, on the contrary, has not undergone signifi cant changes. The Cuprum serum level in experimental calves group remained always signifi cantly higher than in control animals group. “Alphabet for Animals” has a positive eff ect on hemocytopoiesis in calves due to its complex composition (fat-soluble and water-soluble vitamins, aminoacids) and improves the metabolism of microelements, including Ferum and Cuprum. The infl uence on these processes the vitamins of B group, which are a part of this drug, we consider especially valuable in the conditions of the unformed rumen digestion in young cattle.
Key words: vitamin-amino acid complex, erythrocytopoiesis, hypochromia, microcytosis, hemoglobin, color index, hematocrit.
https://orcid.org/0000-0003-3297-454X1. Mel'nyk, A.Ju., Bezuh, V.M., Moskalenko, V.P., Vovkotrub, N.V., Bogatko, L.M., Shhurevych, G.O. (2018). Vplyv preparatu «Abetka dlja tvaryn» na pokaznyky erytrocytopoezu v porosjat [Eff ect of the drug "Alphabet for Animals" on the parameters of erythrocytopoiesis in piglets]. Nauk. visnyk vet. medycyny: zb. nauk. prac' BNAU [Scientifi c herald of veterinary medicine: a collection of scientifi c articles of BNAU]. Bila Tserkva, Vol. 1 (140), pp. 65–71. Available at:http://rep.btsau.edu.ua/handle/BNAU/1414.
2. Levchenko, V.I., Mel'nyk, A.Ju., Moskalenko, V.P., Bezuh, V.M., Bogatko L.M., Shhurevych, G.O., Tyshkivs'kyj, M.Ja., Sakara, V.S. (2017). Vplyv preparatu Gep-A-Stres na obmin rechovyn u kurchat-brojleriv [Eff ect of the drug Gep-AStress on the metabolism of chicken-broilers]. Nauk. visnyk vet. medycyny: zb. nauk. prac' BNAU [Scientifi c herald of veterinary medicine: a collection of scientifi c articles of BNAU]. Bila Tserkva, Vol. 1 (133), pp. 48–55. Available at:http://rep.btsau.edu.ua/handle/BNAU/1415.
3. Levchenko, V.I., Mel'nyk, A.Ju., Bezuh, V.M., Moskalenko, V.P., Harchenko, A.V. (2016). Vplyv preparatu Megavit na A-vitaminnyj i kal'cije-fosfornyj obmin u sil's'kogospodars'kyh tvaryn [Eff ect of Megavit on A-Vitamin and Calcium-Phosphorus Exchange in Farm Animals]. Nauk. visnyk vet. medycyny: zb. nauk. prac' BNAU [Scientifi c herald of veterinary medicine: a collection of scientifi c articles of BNAU]. Bila Tserkva, no. 1 (127), pp. 49–56. Available at:http://rep.btsau.edu.ua/handle/BNAU/289.
4. Levchenko, V.I., Mel'nyk, A.Ju., Moskalenko, V.P., Bogatko, L.M. (2015). Efektyvnist' preparatu Ferolajf za gipoplastychnoi' anemii' porosjat i teljat [Effi ciency of the Ferolift drug for hypoplastic anemia of pigs and calves]. Nauk. visnyk vet. medycyny: zb. nauk. prac' BNAU [Scientifi c herald of veterinary medicine: a collection of scientifi c articles of BNAU]. Bila Tserkva, no. 2, pp. 46–54. Available at:http://rep.btsau.edu.ua/handle/BNAU/283.
5. Levchenko, V., Bohatko, L., Bezukh, V., Moskalenko, V., Melnyk, A. (2016). Novi preparaty dlja likuvannja okremyh vnutrishnih hvorob tvaryn [New drugs for the treatment of individual internal diseases of animals]. Zdorov’ja tvaryn i liky [Health of animals and medicine]. no. 2, pp. 14–18. Available at:http://rep.btsau.edu.ua/handle/BNAU/296.
6. Pavlata, L., Podhorsky, A., Pechova, A., Chomat, P. (2005). Diff erences in the occurrence of selenium, copper and zinc defi ciencies in dairy cows, calves, heifers and bulls. University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic. no. 50, pp. 390–40. Available at: https://doi. org/10.17221/5638-VETMED.
7. Randhawa, C.S., Randhawa, S.S. (2002). Copper status of crossbred cows of the organised and rural dairy herds in central Punjab. Indian Journal of Animal Science. no. 72, pp. 1087–1091. Available at: https://doi.org/10.1079/ BJN19830013.
8. Muehlenbein, E.L., Brink, D.R., Deutscher, G.H., Carlson, M.P., Johnson, A.B. (2001). Eff ects of inorganic and organic copper supplemented to fi rst-calf cows on cow reproduction and calf health and performance. Journal of Animal Science. no. 79, pp. 1650–1659. Available at: https:// doi.org/10.3168/jds.S0022-0302(78)83686-8.
9. Mullis, L.A., Spears, J.W., McCraw, R.L. (2003). Eff ects of breed (Angus vs Simmental) and copper and zinc source on mineral status of steers fed high dietary iron. Journal of Animal Science. no. 81, pp. 318–322. Available at: https://doi.org/10.3168/jds.S0022-0302(00)75055-7.
10. Arthington, J.D., Spears, J.W. (2007). Eff ects of tribasic copper chloride versus copper sulfate provided in corn-and molasses-based supplements on forage intake and copper status of beef heifers. J. Anim. Sci. no. 85, рр. 871– 876. Available at: https://doi.org/10.2527/jas.2006-518.
11. Enjalbert, F., Lebreton, P., Salat, O. (2006). Eff ects of copper, zinc and selenium status on performance and health in commercial dairy and beef herds: retrospective study. J. Anim. Physiol. Anim. Nutr. no. 90, pp. 459–466. Available at: https://doi.org/10.1111/j.1439-0396.2006.00627.x
12. Kamada, H., Nonaka, I., Ueda, Y., Murai, M. (2007). Selenium addition to colostrum increases immunoglobulin g absorption by newborn calves. J. Dairy Sci. no. 90, pp. 5665– 5670. Available at: https://doi.org/10.3168/jds.2007-0348.
13. Shinde, P.L., Dass1, R.S., Garg, A.K. (2009). Eff ect of vitamin E and selenium supplementation on haematology, blood chemistry and thyroid hormones in male buff alo (Bubalus bubalis) calves. Journal of Animal and Feed Sciences. no. 18, pp. 241–256. Available at: https://doi. org/10.22358/jafs/66388/2009.
14. Kinal, S., Korniewicz, A., Slupczynska, M., Bodarski, R., Korniewicz, D., Cermak, B. (2007). Eff ect of the application of bioplexes of zinc, copper and manganese on milk quality and composition of milk and colostrum and some indices of the blood metabolic profi le of cows. Czech J. Anim. Sci. no. 52, 2007 (12), pp. 423–429. Available at: https://doi.org/10.17221/2338-CJAS.
15. Kovzov, V.V. (2014). Sravnitel'naja profi lakticheskaja jeff ektivnost' veterinarnyh preparatov «Feroleks B12» i «Ferrum 10%+B12 [Comparative prophylactic effi cacy of veterinary drugs "Fero lex B12" and "Ferrum 10% + B12]. Uchenye Zapiski UO VGAVM [Scholarly notes VGAVM]. Vitebsk, Vol. 50 (1), pp. 154–158.
16. Kovaljonok, Ju.K. (2013). Mikrojelementozy krupnogo rogatogo skota i svinej v Respublike Belarus': monografi ja [Microelementoses of cattle and pigs in the Republic of Belarus: monograph]. Vitebsk: VGAVM, pp. 40–43, 119–125, 143–152.
17. Kovzov, V.V., Boroznov, S.L. (2009). Pishhevarenie i obmen veshhestv u krupnogo rogatogo skota: monografi ja [Digestion and metabolism in cattle: a monograph]. Minsk: Biznesofset, 316 p. 18. Kuchinskij, M.P. (2007). Biojelementy – faktor zdorov'ja i produktivnosti zhivotnyh: monografi ja [Bioelements – a factor of animal health and productivity: a monograph]. Minsk: Biznesofset, 372 p.
19. Kuchinskij, M.P. (2007). Otrabotka optimal'noj dozy i izuchenie profi lakticheskoj jeff ektivnosti Tetraminerala pri zhelezodefi citnoj anemii porosjat [Testing the optimal dose and the study of the prophylactic effi cacy of Tetramineral with iron defi ciency anemia in piglets]. Veterinarnaja medicina Belarusi [Veterinary medicine of Belarus]. no. 1, pp. 5–11.
20. Banafsheh, Ashraf Hesari., Mehrdad, Mohri., Hesam, A. Seifi . (2012). Eff ect of copper edetate injection in dry pregnant cows on hematology, blood metabolites, weight gain and health of calves. Trop. Anim. Health Prod. no. 44, pp. 1041–1047. Available at: https://doi.org/10.1007/s11250011-0038-4.
21. Naseri, Z., Mohri, M., Aslani, M.R., Tabatabaee, A.A.A. (2011). Eff ects of short-term over-supplementation of copper in milk on hematology, serum proteins, weight gain, and health in dairy calves. Biological Trace Element Research. no. 139, pp. 24–31. Available at: https://doi.org/ 10.1007/s12011-012-9324-x.
22. Arthington, J.D., Havenga, L.J. (2012). Eff ect of injectable trace minerals on the humoral immune response to multivalent vaccine administration in beef calves. J. Anim. Sci. no. 90, pp. 1966–1971. Available at: https://doi.org/ 10.2527/jas.2011-4024.
23. Hansen, S.L., Ashwell, M.S., Moeser, A.J., Fry, R.S., Knutson, M.D., Spears, J.W. (2010). High dietary iron reduces transporters involved in iron and manganese metabolism and increases intestinal permeability in calves. J. Dairy Sci. no. 93, pp. 656–665. Available at: https://doi.org/10.3168/ jds.2009-2341.
24. Pogge, D.J., Richter, E.L., Drewnoski, M.E., Hansen, S.L. (2012). Mineral concentrations of plasma and liver after injection with a trace mineral complex diff er among Angus and Simmental cattle. J. Anim. Sci. no. 90, pp. 2692–2698. Available at: https://doi.org/10.2527/jas.2012-4482.
| Attachment | Size |
|---|---|
 melnyk_2_2019.pdf | 2.44 MB |