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Monitoring of spontaneous neoplasy distribution in dogs in the conditions of Lviv and in the suburban area of the regional center

The article deals with the results of monitoring searches on the spread of cancer in dogs and  conducted the analysis of incidence rates of animals depending on breed, gender and age. Research were performed during the 2016-2019 years on 2015 dogs, who came to the educational research clinics of the Department of Surgery and Diseases of Small Animals named after Stepan Gzhytskyj LNUVMB. Cancer patients sick dogs (n = 259) of diff erent breeds and genders, aged from 4 months to 16 years, were the subject of research. It was installed, that in the structure of surgical diseases of dogs the share of neoplasia averages 12.85% (10.2-14.9% by years of observation). Among neoplasms, breast neoplasia (35.1%) and skin tumors (29.8%) were most commonly reported, less frequently - tumor lesions of the organs of the reproductive system (13.9%),  neoplasia of the internal organs (10.5%), neoplasms in the head and neck (6.6%). Neoplastic lesions of hematopoietic and lymphoid tissues (2.3%) and tumors of bones and joints (1.9%) were characterized by sporadic cases. In 20% of dogs, there was a simultaneous tumor lesion of diff erent nosological forms; most often there are skin and breast tumors, less often skin and tumors in the head and neck. It was also installed, that among 259 dog cancer patients, 23.2% of the animals were outbred and 76.8% were purebred (with more than 40 breeds); males accounted for 48.2% and females for 51.8%. The highest incidence of neoplasia was found in animals between 7 and 12 years of age; the median incidence was 8.5 years, and fashion (the highest number of diseased animals) was 9.5 years. It is found out that the dynamic growth of oncological diseases during 2016-2019 occurred, for the most part, by increasing the number of animals with skin tumors and, to a lesser extent, internal organs. Skin tumors were characterized by a wide variety of nosological forms and were diagnosed in dogs of all ages, as well as diff erent breeds and genders. According to the results of histological verifi cation, 42 or 54.7% of animals had benign tumors of the skin and malignancies in 35 or 45.5% of cases. It was also installed, that benign tumors were mostly represented by papilloma (26.0%), less frequently - lipoma (13.0%), dermatofi broma (10.3%), trichoepithelioma (5.2%). Malignancies are distributed as follows: mastocytoma (18.2%), squamous cell carcinoma adenocarcinoma (2.6 %), spindle cell sarcoma (2.6%) fi brosarcoma (1.3%). Therefore, the reported prevalence of spontaneous neoplasia in dogs in our region certify that skin tumors are currently the most important and promising area for further research.

Key words: dogs, neoplasms, spread, clinical classifi cation of tumors, skin neoplasia, histological type of tumors.

1. Baba, A.I, Câtoi, C. (2007). Comparative Oncology Bucharest: The Publishing House of the Romanian Academy. рр.14–29.

2. Villamil, J.A., Henry, C.J., Bryan, J.N., Ellersieck, M., Schultz, L., Tyler, J.W., Hahn, A.W. (2011). Identifi cation of the most common cutaneous neoplasms in dogs and evaluation of breed and age distributions for selected neoplasms. J. Am. Vet. Med. Assoc. Oct 1.Vol. 239(7), pp. 960–965. Available at:

3. Withrow S.J., et al. (2013). Epidemiology and the evidence-based medicine approach. Animal Clinical Oncology - E-Book. Elsevier Saunders, St. Louis, pp. 69–80.

4. Grüntzig, K., Graf, R., Hässig, M., Welle, M., Meier, D., Lott, G., Erni, D., Schenker, N.S., Guscetti, F., Boo, G., Axhausen, K., Fabrikant, S., Folkers, G., Pospischil, A. (2015). The Swiss Canine Cancer Registry: A Retrospective Study on the Occurrence of Tumours in Dogs in Switzerland from 1955 to 2008. Journal of Comparative Patholog. Vol. 152(2–3), pp. 161– 171. Available at:

5. Willmann, M., Hadzijusufovic, E., Hermine, O. (2019). Comparative oncology: The paradigmatic example of canine and human mast cell neoplasms. Vet Comp Oncol. Vol. 17(1), pp. 1–10. Available at:

6. Garden, O.A., Volk, S.W., Mason, N.J., Perry, J.A. (2018). Companion animals in comparative oncology: One Medicine in action.  The Veterinary Journal. Vol. 240, pp. 6–13. Available at:

7. Brønden, L.B., Flagstad, A., Kristensen, A.T. (2007). Veterinary cancer registries in companion animal cancer: a review. Veterinary and Comparative Oncology. Vol. 5(3), pp. 133–144. Available at:

8. Parker, H.G., Shearin, A.L., Ostrander, E.A. (2010). Man's best friend becomes biology's best in show: genome analyses in the domestic dog Annual Review of Genetics.  Vol. 44, pp. 309–336. Available at: annurev-genet-102808-115200.

9. Pinho, S.S., Carvalho, S., Cabral, J., Reis, C.A., Gärtner, F. (2012). Canine tumors: a spontaneous animal model of human carcinogenesis. Translational Research. Vol. 159(3), pp. 165–172. Available at: trsl.2011.11.005.

10. Gaetano, Gargiulo. (2018). Next-Generation in vivo Modeling of Human Cancers.  Front. Oncol., 10 October. Available at:

11. Webster, J.D., Dennis, M.M., Dervisis, N. (2011). Recommended Guidelines for the Conduct and Evaluation of Prognostic Studies in Veterinary Oncology. Veterinary Pathology. Vol. 48(1), pp. 7–18.

12. Owen, L.N. (1980). TNM Classifi cation of Tumors in Domestic Animals Geneva: World Health Organization.

13. Joshi, S.K., Bhadauria, R.S., Diwaker, A.K. (2012). Introduction to Neoplasm: «Tumor Classifi cation». Joshi and Jadon IJARPB. Vol. 2(2), pp. 227–263.

14. Patnaik, A.K., Ehler, W.J., MacEwen, E.G. (1984). Canine cutaneous mast cell tumor: morphologic grading and survival time in 83 dogs. Vet Pathol. Vol. 21, pp. 469–474.

15. Northrup, N., Geiger, T. (2010). Tumors of the skin, subcutis and other soft tissues. In: Henry C., Higginbotham ML, eds. Cancer Management in Small Animal Practice. Saunders. pp. 299–313.

16. Morris, J., Dobson, J. (2003). Onkologia mallych zwierząt. Sima WLW: Warszawa, 351 p.

17. Hauck, M.L. (2013). Tumors of the skin and subcutaneous tissues. In: Withrow S.J., Vail D.M., Page R., eds. Small Animal Clinical Oncology. 5th ed. St. Louis, MO: Elsevier Saunders. pp. 305–320.

18. Mysak, A.R. (2012). Problema neoplazii u produktyvnykh i dribnykh domashnikh tvaryn [The problem of neoplasia in productive and small pets]. Naukovyi visnyk LNUVM ta BT imeni S. Z. Gzhytskoho [Scientifi c Messenger of Lviv National University of Veterinary Medicine and Biotechnologies]. The Veterinary Science Series. Lviv, Vol. 14, no. 2(52), pp. 250–255.

19. Pustovit, R.V., Danyleiko, Yu.M., Rublenko, M.V. (2006). Monitorynh khirurhichnoi patolohii sered dribnykh domashnikh tvaryn DLVM u Kyivskomu raioni m. Odesy za 2003–2005 roky [Monitoring of surgical pathology among small animals of DLVM in the Kiev region of Odessa for 2003–2005]. Bulletin of Belotserkovsky NAU. Bila Tserkva, Issue 36, pp. 132–137.

20. Rublenko, M.V., Bilyi, D.D. (2012). Poshyrennia spontannykh novoutvoren molochnoi zalozy u sobak v umovakh m. Dnipropetrovsk [Spread of spontaneous breast tumors in dogs in Dnipropetrovsk]. Bulletin of ZhNAEU. Zhytomyr: Polesie, Issue 3, Vol. 1(32), pp. 12–18.

21. Zon, H.A., Ivanovska, L.B., Dobia, M.V. (2013). Rezultaty diahnostyky pukhlyn sobak v m. Sumy [Results of diagnostics of dog tumors in Sumy]. Visnyk Sumskoho NAU: Seriia «Veterynarna medytsyna» [Bulletin of Sumy NAU: Series "Veterinary Medicine"]. Sumy, Issue 9(33), pp. 171–174.

22. Lieshchova, M.O., Shuleshko, O.O., Balchuhov, V.O. (2018). Poshyrennia i struktura novoutvoren tvaryn u misti Dnipro [Distribution and structure of animal neoplasms in the city of Dnipro]. Naukovo-tekhnichnyi biuleten Naukovo-doslidnoho tsentru biobezpeky ta ekolohichnoho kontroliu resursiv APK Dniprovskoho derzhavnoho ahrarnoekonomichnoho universytetu Naukove elektronne vydannia [Scientifi c and Technical Bulletin of the Research Center for Biosafety and Environmental Control of the Agricultural Resources of the Dnipro State Agrarian and Economic University Scientifi c Electronic Edition]. Vol. 6(2), pp. 30–38.

23. Hamota, A.A., Zaviriukha, V.I., Krupnyk, Ya.H., Mysak, A.R. (2007). Pukhlyny tvaryn: etiolohiia, patohenez, diahnostyka, kompleksna terapiia [Tumors of animals: etiology, pathogenesis, diagnostics, complex therapy]. Lviv: Galician Publishing Union.

24. Mysak, A.R. (2010). Zastosuvannia klinichnoi klasyfi katsii pukhlyn za systemoiu TNM pry spontannykh novoutvorenniakh u sobak [Application of clinical classifi cation of tumors according to the TNM system in spontaneous neoplasms in dogs]. Naukovyi visnyk LNUVM ta BT imeni S.Z. Gzhytskoho [Scientifi c Messenger of Lviv National University of Veterinary Medicine and Biotechnologies]. 12, 3(45), рр. 170–176.

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