You are here

TOXICOKINETICS OF CONFODOR 200 SL IN RAT ORGANISM AFTER SINGELE PER ORAL ADMINISTRATION

The results of the study toksykokinetychnyh insecticide properties Konfidor 200 SL (imidaklo-aspiration) following a single administration to rats at a dose of 260 mg / kg body weight. Established that imidacloprid biotransformation in organs and tissues of rats occurs within the first three days of experimental research. The maximum concentration of imidacloprid was detected in the gastrointestinal tract, liver and kidneys.
Key words: toxicokinetics, insecticide, white rats, the remaining amount.

1. Serdjuk A. M. Navkolyshnje seredovyshhe ta zdorov'ja naselennja Ukrai'ny [Tekst] / A. M. Serdjuk // Dovkillja ta zdorov’ja. – 1998. – №4 (7). – S. 2–7.

2. Roberts T. Metabolic Pathway of agrochemicals. P. II, Insecticides and Fungicides [Text] / T. Roberts, D. Huston // Royalsociety of chemistry. – Cornvall, UK. 1999 – P. 107–120.

3. Karl W. [Pyridinyl-14C-methyl] imidacloprid: Distribution of the metabolites in some organs at different times following single oral administration to rats [Text] / W. Karl, O. Klein // Unpublished report from Bayer AG, report No. PF 3635 – Mannheim, 1992. – P. 322–331

4. Klein O. Investigations on the distribution of the total radioactivity in the rat by whole body autoradiography [Text] / O. Klein // Unpublished report from Bayer AG, report No. PF2891. – Mannheim, 1987. – P 782–789.

5. Broznic D. Kinetic evaluation of imidacloprid degradation in mice organs treated with olive oil polyphenols extract [Text] / D. Broznic, J. Marinic, M. Tota // Croaticachemicaacta. – 2008. – Vol. 81, № 1. – P. 203–209.

6. Hanson I. Field study on the insecticidal efficacy of Advantage against natural infestations of dogs with lice. [Text] / I. Hanson, N Mencke, H. Asskildt // Parasitol Res. – 1999. – Vol. 85. – P. 347–348.

7. Filatova O.I. Rozrobka metodyky vyznachennja insektycydu Konfidor 200 SL v produktah tvarynnogo pohodzhennja z vykorystannjam tonkosharovoi' hromatografii' [Tekst] / O.I. Filatova // Vet. medycyna: mizhvid. temat. nauk. zb. – Harkiv, 2013. – Vyp. 97. – S.482–484.

8. Zapadnjuk I.P. Laboratornye zhivotnye: razvedenie, soderzhanie, ispol'zovanie v jeksperimente [Tekst] / I.P. Zapadnjuk, V.I. Zapadnjuk, E.A. Zaharija. – 3-e izd., pererab. i dop. – K.: Vishha shkola, 1983. – 383 s.

9. Kocjumbas I.Ja. Doklinichni doslidzhennja veterynarnyh likars'kyh zasobiv [Tekst] / I.Ja. Kocjumbas. – L'viv: Triada pljus, 2005. – 356 s.

AttachmentSize
PDF icon 2013-12_filatova_en.pdf382.24 KB