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Dynamics of hematological and biochemical parameters in pigs using platelet-enriched fibrin during herniotomy of large hernias

In general, abdominal wall hernias remain a significant problem because they cause considerable discomfort and lead to a number of complications, and the choice of treatment methods depends on the size of the hernial orifice and hernial sac. Herniotomy is the main and most effective method of treating abdominal wall hernias. Techniques that improve soft tissue healing include the use of platelet-enriched f ibrin. The aim of the study was to establish the dynamics of hematological and biochemical parameters during herniotomy of large hernias in pigs using platelet-enriched autofibrin. Control and experimental groups of animals were formed, each of which included pigs with umbilical hernias. After general and local anesthesia, herniotomy was performed in the control group using the classical method, and in the experimental group, platelet-enriched fibrin was additionally used. Blood for morphological and biochemical studies was collected before surgery, on the 3rd, 7th, and 14th days. It was found that in the experimental group there was an early slight increase in the level of leukocytes and platelets. Differences in the leukogram were characterized by an increase in the proportion of eosinophils and segmented neutrophils, a decrease in the proportion of lymphocytes in the experimental group, and an increase in the percentage of monocytes in both groups. Based on the dynamics of acute phase proteins, it was found that in the experimental group, haptoglobin levels were 1.4-1.6 times higher throughout the study period (p<0.001) compared to the control group. The peak concentration of ceruloplasmin was established on the third day in both groups, but no significant differences between the groups were found. The use of platelet-enriched fibrin in the treatment of abdominal wall hernias in pigs does not cause a significant systemic effect on the body and provides a more intense manifestation of the inflammatory resorptive phase. Keywords: platelets, PRF, erythrocytes, leuko cytes, ceruloplasmin, haptoglobin, hernias. > <0.001) compared to the control group. The peak concentration of ceruloplasmin was established on the third day in both groups, but no significant differences between the groups were found. The use of platelet-enriched fibrin in the treatment of abdominal wall hernias in pigs does not cause a significant systemic effect on the body and provides a more intense manifestation of the inflammatory-resorptive phase.

Keywords: platelets, PRF, erythrocytes, leukocytes, ceruloplasmin, haptoglobin, hernias.

SHEVCHENKO S. https://orcid.org/0000-0002-9155-0619


CHEMEROVSKY V. https://orcid.org/0000-0001-5475-5642


TODOSYUK T. https://orcid.org/0000-0002-9856-9793


RUBLENKO M. https://orcid.org/0000-0001-9690-9531


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Scientific Journal of Veterinary Medicine 2'2025