To provide the population of Ukraine with livestock products should intensify research on the creation of highly effective tools and methods for diagnosis, prevention and treatmentof animals and poultry, as well as the use of biotechnologyand genetic engineering, develop an effective system of preventive, sanitary and zoohygienic measures to ensure veterinary welfare, environmental protection, obtaining high qualityproducts. Currently, they are looking for ways to increase theactivity of the natural resistance of animals and poultry withnatural and artificial immunomodulators, pro- and prebioticsand non-drug methods as an alternative to antibiotics.The aim of the study was to investigate the efficacy ofthe prebiotic drug Actigen in the rearing of dose-dependentmeat-producing turkeys.Zootechnical, zoohygienic, hematological and variational-statistical research methods were used to obtain scientificand practical data.The object of study were turkeys of the BIG-6 breed. Theprebiotic Actigen was added to the main diet (OR) of turkeysin the following doses: from the 1st to the 21st day: 0.4; 0.8and 1 g/kg of feed; from the 22nd to the 42nd day: 0.4; 0.6 and0.8 g/kg of feed; from the 42nd to the 120th day: 0.2; 0.4 and0.7 g/kg of feed. Mixing of prebiotic with compound feed wasperformed with a feed mixer on the farm for the productionof compound feed. The bird had free access to food and waterthroughout the fattening. ACTIGEN is a unique second-generation biologically active fraction derived from the outer wallof a specific yeast strain, Sacchamyces cerevisiae, selected byAlltech in the United States and designed to create a moreeffective product for optimizing farm and poultry health. Actigen is a form of yeast carbohydrate. Active substance: 1 kgcontains 280.0 g of crude protein. Pharmaceutical powderform.The results of experimental studies on the effectivenessof the prebiotic Actigen (manufacturer Alltech (U.K.) Limited/Alltech (YK) Limited, UK); which consists of mananoligosaccharides (MOS) isolated from the cell walls of the yeastSaccharomyces cerevisiae.The highest rates of preservation and growth of liveweight of broiler turkeys from the 1st to the 21st day of thepostnatal period of ontogenesis were obtained at a dose of Actigen 0.8 g/kg of feed, which was 3.99 % (P <0.05), obviouslythis is the optimal value.In the case of prebioticAktigen at a dose of 0.6 g / kg offeed, from the 22nd to the 42nd day of the postnatal period ofontogenesis, it was found that the rates of preservation andgrowth of live weight of broiler turkeys were 9.50% (P <0,05)- optimal dose.The use of the prebiotic Actigen from the 42nd to the120th day of the postnatal period of ontogenesis at a dose of0.4 g / kg of feed for broiler turkeys contributed to an increasein the preservation and increase in live weight by 15.31%(P <0.05) optimal value.The most positive effect of Actigen on the morphologicalparameters of poultry blood (hemoglobin content in one erythrocyte) was recorded in the 2nd experimental group, broilerturkeys which used the drug at a concentration of 0.8; 0.6 and0.4 g / kg of feed, depending on age, which contributed toan increase in the amount of hemoglobin in erythrocytes to agreater extent than in the control and other groups - 21.0-25.0% (P <0.05).In the conditions of production the hygienic assessmentof action of drug on productivity is established: increase inlive weight of turkeys, average daily gains of body weight andsafety of a bird.

Key words: industrial poultry farming, growing turkeys,housing conditions, safety, prebiotic, morphological indicators, metabolism, productivity.