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Evaluation of thyroid profile for renal dysfunction in dairy cows

Chronic pathological process in kidney saffect the hypothalamic-pituitary-thyroid system and peripheral metabolism of thyroid hormones. Pathological blood components, which accumulate due to intoxication of metabolic products, the uremic toxins, can affect the metabolism of T3 - and T4 -hormones. In cows on the Ukraine territory such thyroid diseases as hypothyroidism, less often hyperthyroidism, endemic and sporadic goiter, diffuse toxic goiter, tumors were detected, changes in the functional state of the thyroid gland with ketosis, osteodystrophy, hepatodystrophy, polymorbidic pathology were described. Metabolic diseases, which are based on impaired absorption of certain macro-and micronutrients, determine the functional activity of the thyroid gland. The data presented in the article indicate the develop of latent nephropathy in cows during the early milking period with the background of reduced energy supply, which was reflected in the disorders of filtration, excretory and concentration capacity of renal structures with a probable decrease the urea (p<0.001) and creatinine to 3982.4±414.4 μmol/l in urine, a decrease in the value of concentration indices – CI and FCU in 1.7 and 1.4 times, respectively, compared with animals in the control group, the development of hypostenuria with a decrease in relative urinary density to 1.022±0.004 kg/m3 (p<0,01) and selective proteinuria with a probable increase in the protein/ creatinine ratio in 3.14 times compared with the cows of the control group. The disorders of the renal functional state was accompanied by changes in the thyroid profile in cows, which was characterized by a probable increase the T3 hormone level to 4.12±0.55 nmol/l (p<0.05) with a simultaneous decrease in thyroxine to 74.2±13,0 nmol/l (p<0,05) on the background of high values of TSH in blood serum (666.8±51.9 nMO/ml).

Key words: nephropathy, highly productive cows, thyroid gland, thyroxine, triiodothyronine, thyroid-stimulating hormone.

VOVKOTRUB N. https://orcid.org/0000-0003-3297-454X


MELNYK A. https://orcid.org/0000-0001-9129-4814


BEZUKH V. https://orcid.org/0000-0002-8634-946X


TYSHKiVSKI M. https://оrcid.org.//0000-0003-0826-5276


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2020
Scientific Journal of Veterinary Medicine 2'2020