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Mоnitoring the features of the episothology of the talk in scada district of Kherson region

Every year, more than 55,000 people in the world die of rabies, which is confirmed by the data of the WHO expert committee. Up to 40% of victims, from bites sick or suspected of rabies animals are children under the age of 15 years. The source of the rabies agent in 99% of human deaths was dogs.

More than 15 million people around the world receive anti-rabies vaccinations after contact with sick or rabies-pets. According to experts, this prevents 327 thousand deaths from rabies a year.

The susceptibility to skeletal infection of various species of animals, involvement in the epizootic chain, in addition to wildlife, also in domestic and farm animals, has become an extremely high risk for humans, and the lack of means for treating rabies - determine its special place among all contagious diseases.

In the current situation, a rabie must be viewed as an international rather than a local or national problem, so it describes the disease as a global scale noseau [17]. After all, according to the statistics of the International Office of Epizootics (MEB) of the governing body of the World Organization for Animal Health (WHO) cases of rabies recorded in more than 150 countries of the world.

Rabies free are only the countries of Oceania and the United Kingdom, and in other countries the sporadic cases of this deadly disease are recorded. In Europe, this infection in the 50s has become epizootic. The "eradication" of the rabies virus in different countries of Europe during 2008-2015 was conducted in accordance with the developed and implemented Program, where the best results were received in Germany and Switzerland, in these countries the oral immunization of wild carnivores is used (without restrictions on funding).

At the end of the last century, the epicenter of the rabies began to move from Eastern Europe to the territory of Poland (2001-2002), Croatia (2003) and then to the east - to the Russian Federation, the Republic of Belarus, Latvia and Ukraine.

The conducted monitoring of the rabies epizootology have shown that the entire territory of Ukraine is a zone of stable disadvantage of this disease. The peak of epizootics in Ukraine, over the past 65 years, has fallen to 2007 (2393 cases). Since 2008 there were registered from one to two thousand cases of rabies. In 2017 there were registered 1356 cases of animals that were sick on rabies, despite the fact those more than 4.2 million anti-rabies vaccinations of domestic animals. The analysis of the situation shows that from year to year in Ukraine new natural fires of rabies are formed and new types of reservoir animals appear, which leads to an increase in the number of outbreaks of this disease.

The main pledge of successful prevention of rabies around the world is the use of effective anti-rabies vaccines. Despite the regular implementation of planned antiepizootic measures in the southern region of Ukraine (including in the Skadovsk district), there is a tendency to spread the rabies. From year to year, a significant number of rabies in wildlife, domestic and farm animals are recorded on this territory, which is a real threat to the occurrence of the disease among humans.

Investigations of the territory of the Skadovsky district of the Kherson region during the period from 2013 to 2017 showed that 25 cases of rabies were recorded in 15 settlements. To the zone with high tenseness of the epizootic situation, five settlements can be attributed, in which 15 cases of rabies were registered, namely in the villages: Krasnoye and Mykolaivka for four outbreaks, Tarasivtsi three, Ptakovtsi and Blagodatnyi for two. To the zone with low tensity epizootic situation still belongs to 10 settlements, where one case of rabies is registered.

If in 2013 and 2016 there were three rabies outbreaks in four settlements, in 2014 - five cases in 5 villages, and in 2015 - 4 cases in 4 settlements, then in 2017 - 10 outbreaks communicable infection in eight villages of the district. The peak of this epizootic occurred in 2017.

The conducted monitoring showed that the skeletal infection was registered in 38.5% of the Skadovsky district (in 15 out of 39 available settlements). The cases of rabies in different years are interrelated, since repeated outbreaks of this disease are recorded in previously unsuccessful places (Nikolaevka, Tarasivka, Red and Ptahovka), indicating the presence of a constant source and reservoir of communicable infection in this area. It is alarming that in 2017 cases of rabies were first recorded in 6 settlements (Blagodatnoy, Grushivtsi, Oleksandrivka, Petropavlivtsi, Zeleny and Mikhailovna), which testifies to the uncontrolled epizootic situation and the further spread of this infection in the Skadovsky district.

Thus, during the last 5 years, the activity of manifestation of the epizootic process on the territory of Skadovsky area was not marked by stability, there were observed two periods of lifting epizootics of rabies - in 2014 and 2017.

The permanent disadvantages of certain areas of Skadovsky district can be explained, first of all, by the presence of natural cells of the common infection, especially in the steppe part where there are bushes, empty garbage and garbage. Such conditions ensure the existence of a wide variety of wild populations (wolves, red foxes), homeless dogs and stray cats, which promotes the spread of rabies epizootics in this area.

Not the timely destruction of wild animals, the catching of homeless animals that are dangerous to humans, their sterilization, the creation of shelters and proper conditions for maintenance, and in the last three years, not even the holding of oral inoculations of wild animals, has led to the emergence of new anthropological cells feline infections in this region.

Monitoring surveys of all reported cases of rabies in Skadovsk district for 2013-2017 showed that in this area, the source of the rabies was different species of animals - wild, domestic and agricultural.

According to the observations of many scholars, rabies does not belong to seasonal diseases, but in Skadovsk district 20 were recorded in the winter and spring months, namely: 4 outbreaks of this infection were registered in November, December, February and March, 1 in January and 2 in October. From April to August - 5 outbreaks of rabies.

Seasonal cases of rabies coincide with the period of racing of foxes. In the summer, the number of diseases is minimal, because the foxes are busy raising babies, and therefore their mobility is limited. In the autumn, due to young individuals, the population density increases, and accordingly there is a proliferation and new growth of this epizootic. By increasing the population of wolves and foxes, the number of rabies cases among stray dogs and stray cats increases as a result of their contacts.

In the disadvantaged areas of the district, over the past 5 years, 27 cases were diagnosed with rabies animals. Monitoring studies have shown that in 2013 the rabies virus is allocated from 4 diseased animals, in 2014 from 5, in 2015 - 4, in 2016 - 3 and in 2017 - 11 diseased rabies animals. Significant increase in the morbidity rate of animals was noted in 2017.

It is known that different species of animals are susceptible to the rabies virus [1, 2, 6–9, 16, 34]. The conducted studies showed that in the Skadovsky area, the circulation of the virus of cutaneous infection is possible among different animals, because the source of the pathogen was six of their species: foxes, wolves, dogs, cats, large and small cattle.

In the structure of the morbidity of animals in rabies, foxes and cats occupy the leading place with 33.3%, dogs - 14.8%, wolves and cattle - by 7.5% and DRH - 3.7%.

Of the total number of ill in 41% of cases, the source of the rabies virus were wild animals, and 48% were domesticated.

The analysis showed that rabies in Skadovsk district was more often registered among domestic animals - 48% (9 cats and 4 dogs). Among wild animals, patients with rabies were - 41% (11 heads, of which 9 foxes and 2 wolves), and agricultural - 11% (cow, calf and goat). Thus, the statistical data of this region confirm that the source and reservoir of the rabies agent are wild (foxes) and domestic predatory animals (dogs and cats) belonging to the class of mammals.

The epizootic situation in the Skadovsk district from rabies is not catastrophic, but in recent years requires more attention and strengthening measures to combat this problem, because in 2016, the density of fox in the district was 3 heads for 1000 hectares of land; in the norm for example - 0,5 - 1 a goal for 1000 hectares of land. Rating of wolves has not been conducted here, although cases of rabies among this species of animals, for the last 5 years, were recorded twice.

The increased morbidity of dogs, cats and farm animals for scarcity is a sign of epizootic malaise among wildlife. Contributes to the complication of the situation of growth in settlements of the number of homeless dogs and cats, incomplete coverage of preventive vaccinations of domestic animals, violation of the rules for keeping domestic animals by their owners. All this is a prerequisite for the formation of city-type rabies cells, which we observe in Sadovsky district of the Kherson region. In connection with the deterioration of the epizootic situation from rabies, the threat of the onset and spread of this infection among the population increases.

Given that the Skadovsk district of the Kherson region is in the resort zone, and a significant number of Ukrainian and foreign citizens may come to rest on the sea, they must be aware of the epizootic rabies situation in the area in order to protect themselves from the deadly infection.

Key words: contagious infection, dogs, cats, red foxes, wolves, epizootic well-being, morbidity, seasonal manifestations.

1. Atamas, V.Y., Perotskaya, L.V., Maslenikova, S.I. (2008). Osobluvosti epizootologii skazu v pivdennuh oblastyah Ukrainu [Features of rabies epizootology in the southern regions of Ukraine]. Agrarnui visnuk Pruchornomorya [Agrarian Bulletin of the Black Sea Region]. Mykolayiv, Issue 42, pp. 8-12.

2. Achilov, V.G., Nedosekov, V.V. (2013). Harakterustuku epizootuchogo procesu skazu v Khmelnuckii oblasti [Characteristics of the epizootic process of rabies in the Khmelnitsky region]. Veterinary Medicine of Ukraine, no. 6, pp. 14-17.

3. Glebenyuk, V.V. (2014). Harakterustuka epizootuchnogo procesu skazu v Dnipropetrovskii oblasti [Characteristics of the epizootic process of rabies in the Dnipropetrovsk region]. Zbirnuk naukovuh prac’ Lvivskogo NUVMBT imeni
S.Z. Gjuckogo [Collection of scientific Works of the Lviv National Stepan Gzhytsky], no. 2 (59), pp. 17-22.

4. Golik, M.O., Populan, I.M., Nedosekov V.V. (2015). Analiz epizootuchnoi sutuacii zi skazy v Chernigivskii oblasti [Analysis of epizootic situation with rabies in the Chernihiv region]. Veterinary Medicine of Ukraine, no. 5, pp. 5-8.

5. Golovko, M.A. (2013). Analiz epizootuchnoi sutuacii v Ukraini shodo skazu [The analysis of the epizootic situation in Ukraine concerning rabies]. Vet. Biotehnologiya: Bull. NAAN. Instutu vet. meducunu [Vet. Biotechnology: Bulletin of the National Academy of Agrarian Sciences]. Kyiv, Issue 23, pp. 61-63.

6. Gridko, A.I. (2013). Rol dukuh tvarun u poshurenni skazu [The role of wild animals in the spread of rabies]. Veterinary Medicine of Ukraine, no. 3, pp. 37-38.

7.. Derjprodspojuvslujba Ukrainu [State Committee for Consumer Goods of Ukraine]. Retrieved from:

8. Levkovsky, D.M., Levkivska, N.D., Storchak Y.G. (2016). Epizootologichnui monitoring skazu tvarun u Lvivskii oblasti za 2014-2016 roku, analiz provedennya anturabichnuh zahodiv. [Epizootological monitoring of rabies of animals in the Lviv region for 2014-2016, analysis of anti-rabbinical measures]. Zbirnuk naukovuh prac’ Lvivskogo NUVMBT imeni S.Z.Gjuckogo. [Collection of scientific Works of the Lviv National Stepan Gzhytsky University of Veterinary Medicine and Biotechnology named after Gzhytskyi], no. 3 (71), pp. 50-51.

9. Epizootuchna sutuaciya schodo nebezpechnuh hvorob tvarun u sviti.  [Epizootic situation concerning dangerous animal diseases in the world]. Veterinary practice, Journal Source, official Chronicle,2017, no. 12, 2.p.

10. Zavoloka, A. A., Zavoloka, A. A. (2014). Sovremennue osobennosti epizooticheskogo processa [Rabies Modern features of the epizootic process]. Modern Veterinary medicine, no. 1, pp. 70-76.

11. Karchevska, T.M., Chumakov, K.A., Petruk, E.O. (2017). Monitorung skazu [Monitoring of rabies]. Health of Animals and Medicine, no. (191), pp. 13.

12. Makarov, V.V., Vorobyov, A.A. (2005). Aktualnie problem beshenstva: prirodnaya ochagovost. Metodologiya issledovanii I kontrolya v centre Rossii [Actual problems of rabies: natural foci, research and control methodology in the center of Russia]. Journal microbiology Epidemiology and Immunobiology, no. 1, pp. 90-95.

13. Stryzhak, L.F. (2016), U borotbi zi skazom golovne - sustemnist. [In a struggle with rabies the main thing is systemicity]. Health of Animals and Medicine, no. 2, 19.p.

14. Expert Consultation on Rabies. Technical Report Series 931. WHO. 2005, 121 p.

15. Expert Consultation on Rabies. Technical Report Series 982. World Health Organization. 2013, 139 р.

16. Freuling, C., Selhorst, T., Kliemt, A., Muller, T. Rabies surveillance in Europe, 2004–2007. Rabies Bulletin Europe. 2007, Vol. 31, no. 4, pp. 7–9.

17. Guo, L., Feng, N., Yang, S. Reverse genetic system for rabies virus vaccine Evelyn-Rokitnicki-Abelseth strain. Wei Sheng Wu Xue Bao. 2009, Vol. 4, no 49 (7), pp. 949–954.

18. Ivanov, M., Polupan, I., Deryabin, O. The Activity Rabies Vaccines against Genetic Clusters of Rabies Virus Circulating at the Territory of Ukraine. Online Journal of Public Heath Informatics (OJPHI). Vol. 5, 1(2013), Shecial Issue, 101.p.

19. Johnson, N., Cunningham, F., Fooks, R. The immune response to rabies virus infection and vaccination. Vaccine. 2008, Vol. 28, pp. 3896–3901.

20. Kumar, M., Singh, P., Mishra, B. Development of alternative approaches for in-process quality control of rabies vaccine. Advanses in animal and veterinary sciences. 2014, Vol. 2(3), pp. 164–170.

21. Manual of diagnostic test and vaccines for terrestrial animals. Chapter ed. OIE. Geneva, 2008, pp. 304–323.

22. Kuzmin, I., Botvinkin, A., McElhinney, L. Molecular epidemiology of terrestrial rabies in the former Soviet Union. J. Wildlife Dis. 2004, Vol. 40, pp. 617–631.

23. Morters, K., McKinley, J., Horton, L. Achieving Population-Level Immunity to Rabies in Free-Roaming Dogs in Africa and Asia. PLOS Neglected Tropical Diseases. 2014, Vol. 8, no. 11, pp. 314–318.

24. Park, Y., Shin, M., Kwon, H. Genetic characterization of rabies virus isolates in Korea. Virus Genes. 2005, Vol. 30, pp. 341–347.

25. Polupan, I., Ivanov, N., Deryabin, O., Skripnik, V. Molecular Epizootiology of Street Rabies Virus Isolates in Ukraine. Abstracts Book 10-th ASM Biodefense and Emerging Diseases Research Meeting. 2012, 55.p.

26. Rupprecht, C. Oral vaccination of dog with recombinant rabies virus vaccines. Virus Research. 2005, Vol. 111,
pp. 101–105.

27. Rupprecht, C. E., Kuzmin, I.V. Why we can prevent control and possiblytreat but will not eradicate rabies. Future Virol. 2015, Vol. 10(50), pp. 517–535.

28. Schiffelers, M.J., Blaauboer, B., Bakker, W., Hendriksen C. Replacing the NIH test for rabies vaccine potency testing: A synopsis ofdrivers and barriers. Biologicals. 2014, Vol. 35, pp. 1–13.

29. Schiffelers, M.J., Blaauboer, B., Bakker, W., Hendriksen, C. Regulatory acceptance and use of serology forinactivated veterinary rabies vaccines. ALTEX. 2015, Vol. 32(3), pp. 211–221.

30. Siili, J., Benisek, Z., Svrcek, S. Injectious rabies vaccines effectiveness evalution alternatives. Acta Veterinaria. 2007, Vol. 57, no. 1, pp. 17–26.

31. Siili, J., Benisek, Z., Ondrejkova, A. A new rabies vaccine with an experimental adjuvant for domestic animals. Acta Veterinaria. 2010, Vol. 60, pp. 597–603.

32. Wandeler, A.I. Rabies Vaccinology and Immunology. First International Conference on Rabies in Europe. 2005, pp. 181–185.

33. Wasniewskia, M., Labbe, F., Tribout, L. Evaluation of a Rabies ELISA as an alternative method toseroneutralisation test in the context of international trade of domestic carnivores. Journal of Virological Methods. 2014, Vol. 195, pp. 211–220.

34. Wasniewskia, M., Guiotb, L., Schereffera, L. Evaluation of an ELISA to detect rabies antibodies in orally vaccinated foxes andraccoon dogs sampled in the field. Journal of Virological Methods. 2013, Vol. 187, pp. 264–270.

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