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Nonspecifi c resistance of the rabbits organism in case of рassalurosis
Researching the characteristics of immunity is the best way for eff ective prevent and treat the diseases. Helminthiasis immunity has a number of features that are caused by relationships in the host-parasite system. Passalurosis is quantitatively dominant among many types of rabbit helminths on the globe. The goal of the work was to determine the infl uence of Passalurus ambiguuson indicators nonspecifi c resistance of the rabbits organism. Analog groups of male rabbits of 3-5 months old were selected for the experiments. Intensity of invasion was determined by the method of the Mac-Master.Rabbits with рassalurosis had diff erent levels of invasion intensity (II): low (II = 276.47 ± 43.33 eggs in 1 g of feces)–І, medium (II=1293.75 ± 275.80 eggs in 1 g of feces) – II and high (II= 2446.67 ± 422.11 eggs in 1 g of feces) – III research groups. We did not fi nd helminth’s eggs in the control group. It was found that in blood of sick animals with high II phagocytic activity is lower than in blood of healthy ones by 9.71% (p<0.01)A low indicator of phagocytic activity shows depressed phagocytosis in the organism of animals suff ering from рassalurosis of rabbits. In these rabbits, the phagocytic number was probably lower by 14.08% (p<0.01) compared to the control. Low levels of BASK and LASK were observed in infected animals by 5.45% (p<0.05), 8.00% (p<0.01), 14.49% (p<0.001) and 4.15% (p<0.001), 5.22% (p<0.001), 7.04% (p<0.001), respectively, in animals I , II and III groups than in the control. The decrease in the se in dicators in sick animals in dicates a weakening of the factors of non specifi c natural resistance of the organism. Analyzing the level of circulating immune complexes, we found a high level of medium and small CIC in clinically ill rabbits with low, medium and high II, respectively, 2.23 times (p <0.001), 2.37 times (p <0.001), 2.74 times (p <0.001) and 1.95 times (p<0.01), 2.09 times (p<0.001) and 2.22 times (p<0.001), against the control. An increase in the leve of CІC indicated the development of immunotoxicosis syndrome, the se verity of which correlated with the level of ІI of the disease.
Key words: phagocytic activity, bactericidal activity, lysozyme activity, Circulating immune complexes, рassalurosis, Passalurus ambiguus.
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