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Pathogenetic foundations and modern approaches to the pharmacotherapy of broncho pneumonia in production animal

Bronchopneumonia is among the most prevalent respiratory disorders in animals, causing significant economic losses in livestock production due to decreased productivity, treatment costs, and mortality of young animals. This review summarizes current knowledge on the prevalence, etiology, and pathophysiological mechanisms of bronchopneumonia in animals, emphasizing the roles of microbial–viral associations, cytokine cascade activation, oxidative stress, and hypoxic tissue injury. Modern pharmacotherapeutic strategies are analyzed, integrating etiological, pathogenetic, and symptomatic approaches. Particular attention is paid to the combined use of antimicrobial agents with anti-infl ammatory, mucolytic, antioxidant, and immunomodulatory drugs aimed at restoring respiratory function and systemic homeostasis. The paper discusses the shortcomings of conventional antibiotic therapy, such as the emergence of antibiotic resistance and the insufficient consideration of pathophysiological conditions in diseased animals. Promising research directions are outlined, including bacteriophage therapy, antimicrobial peptides, nanocarrier-based drug delivery systems, natural antioxidants, and probiotic formulations. The importance of pathophysiologically grounded and personalized approaches to therapy, considering immune reactivity, respiratory microbiome composition, and environmental management, is emphasized. The presented synthesis highlights strategies to enhance therapeutic efficacy, reduce relapse frequency, and achieve sustainable recovery in animals affected by bronchopneumonia.

Keywords: bronchopneumonia, production animals, pathophysiology, treatment, antibiotic resistance, pharmacological therapy.

SHAGANENKO V. https://orcid.org/0000-0003-3484-2962


RUBLENKO S. https://orcid.org/0000-0003-0678-5497


KOZII N.


SHAGANENKO R. https://orcid.org/0000-0002-5848-1367


AVRAMENKO N. https://orcid.org/0000-0003-2200-1322


SHMAYUN S. https://orcid.org/0000-0001-6458-6336


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Scientific Journal of Veterinary Medicine 1'2026