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Correction of inflammatory regeneration processes in pigs after hernia repair Avesstim

In a clinical study found probable (p<0,05) reduction of healing of wounds in animals of experimental group an average of 2,4 ±
0,7 days. Healing the wounds they have occurred at primary intention operational stitches removed on the 7th day. Complications
during the healing process have not noted.
However, in two animals in the control group extension for healing was a festering and subsequent complication due to slow
granulation and differences edges of the walls of the wound, followed by healing by secondary intention.
In the treatment of postoperative wounds probable deviations morphological and biochemical parameters of blood were found.
However,  one  should  note  the  tendency  to  reduce  the  number  of  white  blood  cells  in  the  3rd  and  7th  day  of  treatment  in  the
experimental  group  of  animals,  while  control  on  the  7th  day  the  number  of  leukocytes  contrary  increased.  In  general,  this  may
indicate a lack of effective constraints inflammation or its complications inflammatory process.
Leykoformula analysis revealed no significant alteration of the neutrophils, but should pay attention to the sharp increase in
eosinophils in the experimental group on 3rd – 5,8 ± 0,77, to lower – 3,60 ± 0,51 on the 7th day. What we believe is associated with
an active course of reparative processes, basic plasma activation system, including alternative route of complement  activation in
inflammatory  response  Avesstim.  However,  eosinophils  play  an  important  role  in  the  formation  and  transport  antymediators
inflammation.  Eosinophils  not  only  absorb  antigens  and  immune  complexes,  and  isolated  and  almost  all  antymediator  enzymes:
histaminase,  carboxypeptidase,  esterase,  prostahlandyndehidrohenaze,  catalase,  arylsulfatazu  thus  maintaining  optimum  mode
mediator of inflammation. By the 7th day reduced levels of eosinophils and close to the level that was before the surgery.
On the third day in the experimental group found significantly lower levels of lymphocytes compared to controls. This indicates
heavy use of lymphocytes and their accumulation in the inflammation that will positively affect the dynamics of the regenerative
Research  hemostasis  major  indicators  including  FXIII  fibrinogen  and  reflects  the  dynamics  inherent  to  inflammation.  FHIII
significantly reduced to 3rd day in both groups due to its intensive use in this period. The sharp decrease in fibrinogen in the control
group on the 7th day – 1,70 ± 0,42 g / l may be a reflection of consumption coagulopathy that occurred through intense inflammatory
reaction in the healing of postoperative wounds.
However, in the experimental group use of Avesstim caused significant increase of NOx 76,1 ± 4,59 and hold it throughout the
observation period 69,0 ± 6,65 mmol / l.
In the control group of animals NOx lowest rate – 49,3 ± 3,75 mmol / l, against a background of low levels of fibrinogen – 1,70
± 0,42 g / l indicates the development deficit of coagulation factors by prolonged inflammation, since NO produced by leukocytes in
terms of inflammatory response.
Wounds  after  operation  are  prone  to  septic  complications,  accompanied  by  increasing  deficit  of  natural  anticoagulants,
decreased activity FXIII factors and predisposition to the development of coagulopathy.
Supplement traditional treatment schemes and immunostimulant Avesstim prevents the development of coagulopathy in sick
animals increases the activity FXIII, levels of nitric oxide and eosinophils in the blood., Which clinically manifested in shortening the
recovery of patients by 2.4 days compared with conventional treatment.
Prospects for further research is to study the effectiveness of the drug in other forms of lymphoma surgical pathology in pigs
and other farm animals.
Key words: hernia, pigs, adjuvants, wounds, Avesstim.

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