The article presents aspects of accidental wounds in dogs that are usually infected with associations of microorganisms (Str. Facials, Staph., Eridermidis, Staph. Aureus, Str. Phyogenes, Str., Methenteroides, Str. Fecalis, E. Coli, Cl. Sporogenes). By results of researches it is established, that the wound microflora is most sensitive to cephalosporins and macrolides. In the natural counteraction of microbial aggression, I actively participate in myeloperoxidase, phagocytosis and lysozyme.

Contamination of the wound in dogs by purulent microorganisms suprovodzhuetsya neutrophilic leukocytosis and a probable increase in the blood of the number of segmented neutrophils and the appearance of young. These signs indicate a "nuclear shift left".

The wound microflora is most sensitive to cephalosporins and macrolides. Myeloperoxidase, phagocytosis and lysozyme actively participate in the natural counteraction of microbial aggression in connection with accidental wounds.

Damaged tissue throws a number of biologically active substances that cause wound pathogenesis. There is depolymerization of the matrix, there is swelling, tissue acidosis, hypoxia. Inducers in the development of catabolic processes are lysosomal and other enzymes, degranulation products of tissue basophils.

The process of wound healing is provided by the action of short-range regulators on the cellular and sub-cellular levels. So, platelets emit the so-called platelet growth factor of fibroblasts (the main stimulant for healing wounds under the scrotum).

Pathogens of inflammatory local processes in the wound are mainly staph. erydégmidi, Staph. aureus, str. Ruogenes, Str. mеsеntегоіdеs, Str. fesaly Occasionally they joined Sl. srооgеnеs In addition, wound healing of E. coli in association with CI was relatively common. peggiegenns

Sensitivity of the microorganisms of the wound exudate to the antibiotics showed that Staph. eredegmides, was sensitive to cephalosporin I generation (cephazolin) and to oleandomycin (antibiotic macrolide series), to a lesser extent to cefaclor (cephalosporin II generation).

In dogs with severe wound inflammation, the number of microorganisms in 1 ml of exudate was 106-109, that is, exceeded the critical level of 105. The excess of the critical limit of the presence of microorganisms is considered to be the main cause of suppuration of casual wounds. However, suppuration was manifested also in a significantly smaller number of microorganisms in the exudate, especially in the presence of fragments of dead tissues, extraneous bodies in the wound, as well as in the case of reduced reactivity of the organism.

To the rest of the antibiotics – penicillin sodium salt, ampicillin, kanamycin, doxycycline, this microorganism was weakly sensitive or completely insensitive. Staph aureus, was sensitive to cefaclor and oleandomycin. St ruogenes, was sensitive to doxycycline and cefazolin and was slightly sensitive to kanamycin, cefaclor, and oleandomycin.
St mеsеntегоіdеs, was sensitive to cefazolin, cefaclor, and олеадомицину and is weakly sensitive to ampicillin and доксициклина. St Fesalius was sensitive to oleandomycin and weakly sensitive to kanamycin, cefazolinum and cefaclor, E. coli was sensitive to oleandomycin and slightly sensitive to doxycycline and cefaclor. Sl. The sroorogenesis was susceptible to doxycycline, cefaclor, and oleandomycin and slightly susceptible to Sl. Sroorogenesis was susceptible to doxycycline, cefaclor, and oleandomycin, and slightly sensitive to benzylpenicillin sodium, ampicillin, and cefazolin. Sl. Regfigingen was sensitive to cefaclor and oleandomycin and was slightly sensitive to kanamycin and cefazolin

The state of nonspecific resistance, in the characteristic of the course of wound process with random purulent wounds, significantly increases from 6 to 12 days inclusive. The activity of microbicidal factors of neutrophil myeloperoxidase (average cytochemical coefficient) on the 6th and 12th day of the wound's existence, relative to the control) is 1.32 ± 0.04, 1.42 ± 0.103; the phagocytic activity of neutrophils (%) also rises from 57.0 ± 1.12 to 57.0 ± 1.12 ; accordingly, natural resistance is increasing in terms of the limits of the phagocytic activity of neutrophils (%) from 57.0 ± 1.12  to 60.0 ± 1.57 with respect to control. The microbicidal activity (excluding the lysozyme content) of the phagocytic index of neutrophils (μ/kl) also increases.

Thus, the microorganisms of the wound exudate exhibited resistance to most antibiotics that were used in the experiment. At the same time, E. coli and Str showed the greatest antibiotic resistance. fesaly The least resistant microorganisms were to cephalosporins and macrolides – antibiotics that began to be used relatively recently, and the most resistant to antibiotics that were used for a long time – benzylpenicillin sodium salt, ampicillin, kanamycin.

Counteraction of microbial aggression is carried out with the active participation of neutrophil granulocytes, phagocytosis, lysozyme and other microbocidal factors of an animal organism. Their activity at random purulent wounds in dogs.

Key words: dogs, wound, resistance, skin, blood, exudate.