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Evaluation of thyroid profile for renal dysfunction in dairy cows

Chronic pathological process in kidney saffect the hypothalamic-pituitary-thyroid system and peripheral metabolism of thyroid hormones. Pathological blood components, which accumulate due to intoxication of metabolic products, the uremic toxins, can affect the metabolism of T3 - and T4 -hormones. In cows on the Ukraine territory such thyroid diseases as hypothyroidism, less often hyperthyroidism, endemic and sporadic goiter, diffuse toxic goiter, tumors were detected, changes in the functional state of the thyroid gland with ketosis, osteodystrophy, hepatodystrophy, polymorbidic pathology were described. Metabolic diseases, which are based on impaired absorption of certain macro-and micronutrients, determine the functional activity of the thyroid gland. The data presented in the article indicate the develop of latent nephropathy in cows during the early milking period with the background of reduced energy supply, which was reflected in the disorders of filtration, excretory and concentration capacity of renal structures with a probable decrease the urea (p<0.001) and creatinine to 3982.4±414.4 μmol/l in urine, a decrease in the value of concentration indices – CI and FCU in 1.7 and 1.4 times, respectively, compared with animals in the control group, the development of hypostenuria with a decrease in relative urinary density to 1.022±0.004 kg/m3 (p<0,01) and selective proteinuria with a probable increase in the protein/ creatinine ratio in 3.14 times compared with the cows of the control group. The disorders of the renal functional state was accompanied by changes in the thyroid profile in cows, which was characterized by a probable increase the T3 hormone level to 4.12±0.55 nmol/l (p<0.05) with a simultaneous decrease in thyroxine to 74.2±13,0 nmol/l (p<0,05) on the background of high values of TSH in blood serum (666.8±51.9 nMO/ml).

Key words: nephropathy, highly productive cows, thyroid gland, thyroxine, triiodothyronine, thyroid-stimulating hormone.

VOVKOTRUB N. https://orcid.org/0000-0003-3297-454X


MELNYK A. https://orcid.org/0000-0001-9129-4814


BEZUKH V. https://orcid.org/0000-0002-8634-946X


TYSHKiVSKI M. https://оrcid.org.//0000-0003-0826-5276


  1. Sakhniuk, V.V. (2003). Funktsionalnyi stan shchytopodibnoi zalozy u vysokoproduktyvnykh koriv [Functional condition of the thyroid gland in highly productive cows]. Visnyk Bilotserkiv. derzh. ahrar. un-tu: Zb. nauk. prats. [Bulletin of Bila Tserkva State Agrarian University: a collection of scientific papers]. Bila Tserkva, Issue 25, Part 3, pp. 5–17.
  2. Levchenko, V.I., Vlizlo, V.V., Kondrakhin, I.P. (2019). Veterynarna klinichna biokhimiia: pidruchnyk [Veterinary clinical biochemistry: a textbook]. Bila Tserkva: BNAU, 416 p.
  3. Schultheiss, U.T., Daya, N., Grams, M.E. (2017). Thyroid function, reduced kidney function and incident chronic kidney disease in a community-based population: the Atherosclerosis Risk in Communities study. Nephrol Dial Transplant. Vol. 32, pp. 1874–1881. Availadle at: https://doi. org/10.1093/ndt/gfw301.
  4. Duntas, L.H., Biondi, B. (2011). New insights into subclinical hypothyroidism and cardiovascular risk. Semin Thromb Hemost. Vol. 37, pp. 27–34. Availadle at: https://doi. org/10.1055/s-0030-1270068.
  5. Feinstein, E.I., Kaptein, E.M., Nicoloff, J.T., Massry, S.G. (1982). Thyroid function in patients with nephrotic syndrome and normal renal function. Am J Nephrol. Vol. 2(2), pp. 70–76. Availadle at: https://doi.org/10.1159/000166587.
  6. Gattineni, J., Sas, D., Dagan, A., Dwarakanath, V., Baum, M.G. (2008). Effect of thyroid hormone on the postnatal renal expression of NHE8. Am J Physiol Renal Physiol. Vol. 294(1), pp. 198–204. Availadle at: https://doi. org/10.1152/aiprenal.00332.2007.
  7. Katyare, S.S., Modi, H.R., Patel, S.P., Patel, M.A. (2007). Thyroid hormone-induced alterations in membrane structure-function relationships: studies on kinetic properties of rat kidney microsomal Na(C),K (C)-ATPase and lipid/ phospho-lipid profiles. J Membr Biol. Vol. 219(1–3), pp. 71– 81. Availadle at: https://doi.org/10.1007/s00232-007-9063-7.
  8. Orlova, M.M., Rodyonova, T.Y. (2013). Sostoianye funktsyy pochek u patsyentov s hypotyreozom (obzor) [Renal function status in patients with hypothyroidism (review)]. Medytsynskyi almanakh [Medical almanac]. pp. 112–114.
  9. Levchenko, V., Bezukh, V., Romaniuk, V., Fasolia, V. (2001). Khvoroby shchytopodibnoi zalozy [Ailments shieldlike zalozi]. Vet. medytsyna Ukrainy [Veterinary medicine of Ukraine]. no. 6, pp. 35–37.
  10. Kondrakhyn, Y.P. (2007). Jendokrinnye, allergicheskie i autoimmunnye bolezni zhivotnyh: Spravochnik [Endocrine, allergic and autoimmune diseases of animals: Handbook]. Moscow: KolosS, 251 p.
  11. Levchenko, V., Romaniuk, V., Symerenko, L. (1999). Symerenko Funktsiia shchytovydnoi zalozy u teliat z urodzhenym zobom [The function of the thyroid gland in calves with urogenital goiter]. Vet. medytsyna Ukrainy [Veterinary medicine of Ukraine]. no. 11, pp. 8–10.
  12. Vlizlo, V.V., Simonov, M.R., Petrukh, I.M. (2010). Funktsionalnyi stan shchytopodibnoi ta pryshchytopodibnykh zaloz u zdorovykh i khvorykh na ketoz koriv [Functional condition of the thyroid and thyroid glands in healthy and ketosis cows]. Naukovyi visnyk veterynarnoi medytsyny: Zb. nauk. Prats [Scientific Bulletin of Veterinary Medicine: a collection of scientific papers]. Bila Tserkva, Issue 5 (78), pp. 41‒43.
  13. Simonov, M.R. (2016). Biokhimichnyi ta hormonalnyi status u zdorovykh i khvorykh na ketoz vysokoproduktyvnykh koriv: dys. … d-ra vet. nauk: 03.00.04. [Biochemical and hormonal status in healthy and patients with ketosis of highly productive cows: the dissertation of the doctor of veterinary sciences: 03.00.04.]. Lviv, 338 p.
  14. Periklis, Dousdampanis., Konstantina, Trigka, Georgios, A. Vagenakis, Costas, Fourtounas. (2014). The thyroid and the kidney: a complex interplay in health and disease. Int J Artif Organs. Vol. 37(1), pp. 1–12. Availadle at: https://doi.org/10.5301/ijao.5000300. Epub 2014 Jan 20.
  15. Kaptein, E. M. (1997). Clinical Relevance of Thyroid Hormone Alterations in Nonthyroidal Illness. Thyroid Int. Vol. 4, pp. 22–25.
  16. Basu, G., Mohapatra, A. (2012). Interactions between thyroid disorders and kidney disease. Indian J. Endocr. and Metabolism. no. 16 (2), pp. 204–213.
  17. Dudar, I.O., Savchuk, D.M., Loboda, O.M., Abrahamovych, Kh.Ia., Krasiuk, E.K. (2018). Tyreoidni porushennia u patsiientiv z khronichnoiu khvoroboiu nyrok [Thyroid disorders in patients with chronic kidney disease]. Aktualni problemy nefrolohii [Current problems of nephrology]. Issue 24, pp. 9–12.
  18. Brüngger, M., Hulter, H. N., Krapf, R. (1997). Effect of chronic metabolic acidosis on thyroid hormone homeostasis in humans. Am. J. Physiol. no. 272, pp. 648–653.
  19. Pedro, Iglesias, María, Auxiliadora Bajo, Rafael, Selgas, Juan, José Díez. (2017). Thyroid dysfunction and kidney disease: An update. Rev Endocr Metab Disord. Vol. 18(1), pp. 131–144. Availadle at: https://doi.org/10.1007/ s11154-016-9395-7.
  20. Capasso, G., De Tommaso, G., Pica, A. (1999). Effects of thyroid hormones on heart and kidney functions. Miner Electrolyte Metab. Vol. 25(1-2), pp. 56–64. Availadle at: https://doi.org/10.1159/000057421.
  21. Klar, S. (1987). Pochky y homeostaz v norme y pry patolohyy /per. s anhl. [Kidneys and homeostasis are normal and in pathology / translated from English]. Moscow: Medicine, 102 p.
  22. Vovkotrub, N.V. (2005). Nefrotychnyi syndrom u vysokoproduktyvnykh koriv i novonarodzhenykh teliat (patohenez, diahnostyka i likuvannia): avtoref. dys. … kand. vet. nauk. [Nephrotic syndrome in highly productive cows and newborn calves (pathogenesis, diagnosis and treatment): abstract of the dissertation of the candidate of veterinary sciences]. Bila Tserkva, 22 p.
  23. Romashkyna, E.A. (2016). Harakteristika strukturnyh osobennostej pochek v uslovijah ugnetenija funkcii shhitovidnoj zhelezy [Characterization of the structural features of the kidneys in conditions of inhibition of the thyroid gland function]. Biomedcal and Biosocial Antropology. no. 26, pp. 94‒98.
  24. Doletskyi, S.P. (2010). Funktsionalnyi stan shchytopodibnoi zalozy u vysokoproduktyvnykh koriv u razi zastosuvannia veterynarnoho preparatu Minpankor [Functional condition of the thyroid gland in highly productive cows in the case of the use of the veterinary drug Minpankor]. Naukovyi visnyk veterynarnoi medytsyny: zb. nauk. prats. [Scientific Bulletin of Veterinary Medicine: a collection of scientific papers]. Bila Tserkva, Issue 5 (78), pp. 24‒31.
  25. Clinical Practice guidelines for hypothyroidism in adults: American Association of Clinical Endocrinologists (AACE). American Thyroid Association (ATA). 2012. Vol. 18 (6).
  26. Melnyk, A.A. (2019). Dysfunktsyia shchytovydnoi zhelezy y zabolevanyia pochek [Thyroid dysfunction and kidney disease]. Nyrky [Kidneys]. Vol. 8, no. 1, pp. 68–78. Availadle at: https://doi.org/10.22141/2307-1257.8.1.2019.157798 .
  27. Volkova, A.R., Dyhun, O.D., Lukychev, B.H., Dora, S.V., Halkyna O.V. (2018). Disfunkcija shhitovidnoj zhelezy pri hronicheskoj bolezni pochek: sostojanie problemy i puti reshenija [Thyroid dysfunction in chronic kidney disease: the state of the problem and solutions]. Nephrology. Issue 22 (4), pp. 40–49. Availadle at: https://doi.org/10.24884/1561-6274-2018-22-4-40-49.
  28. Herasymov, H.A. (1998). Laboratornye metody v diagnostike zabolevanij shhitovidnoj zhelezy [Laboratory methods in the diagnosis of thyroid disease]. Klin. labor. diagnostika [Clinical laboratory diagnostics]. no. 6, pp. 25–32.
  29. Åsvold, B.O., Bjøro, T., Vatten, L.J. (2011). Association of thyroid function with estimated glomerular filtration rate in a population-based study: The HUNT study. Eur J Endocrinol. Vol. 164, pp. 101–105. Availadle at: https:// doi.org/10.1530/EJE-10-0705.
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2020
Scientific Journal of Veterinary Medicine 2'2020