You are here

Diseases of the reproductive system caused by infectious diseases

A typical manifestation of some infectious diseases is damage to the reproductive system of the body, which is accompanied by abortions and their complications, namely: retained placenta, metritis, vulvovaginitis, mastitis, infertility in females; orchitis and balanoposthitis in males, which is associated with the tropism of the pathogens of these infections to the tissues of the reproductive organs. That is, impaired reproductive function in animals is often the result of infectious pathologies. Such diseases as brucellosis, leptospirosis, listeriosis, tularemia, chlamydia, campylobacteriosis are quite often the cause of abortions and other pathologies of the reproductive system in both animals and humans. The main method of their diagnosis and differentiation is laboratory bacteriological, serological, luminescent microscopic and molecular genetic studies. To cure these diseases, anti-epizootic measures and therapeutic and prophylactic agents have been developed and implemented, which allow diagnosing and controlling such infections, conducting effective treatment of sick animals and preventive treatments, including using immunobiological vaccine preparations. Systematic implementation of preventive and health-improving measures has led to the eradication in Ukraine of such an extremely dangerous infectious disease common to animals and humans as brucellosis of cattle and small cattle (causative agents Br. melitensis, Br. abortus). Vaccination plays an important role in the complex of measures for the treatment of brucellosis in animals. Live vaccines are used, made from weakly virulent, attenuated immunogenic strains. Immunization with live vaccines creates non-sterile immunity, which over time turns into sterile immunity. Experience in the use of live vaccines has shown that the drugs are effective when used to combat brucellosis in combination with veterinary-sanitary, economic and administrative-economic measures. At the same time, such diseases as leptospirosis, listeriosis, tularemia, chlamydia, campylobacteriosis, despite the developed effective measures of prevention and control, are occasionally registered and can lead to quite severe epizootic situations and cause significant economic losses. Anti-epizootic preventive and health-improving measures provided for the current instructional materials on these diseases allow controlling the epizootic situation with the prospect of improving the health of disadvantaged herds.

Key words: brucellosis, leptospirosis, listeriosis, tularemia, chlamydia, campylobacteriosis.

  1. Moore, D.P., Cantón, G.J., Louge, Uriarte, E.L. (2021). Editorial: Infectious Diseases Affecting Reproduction and the Neonatal Period in Cattle. Front Vet Sci., Vol. 8. DOI:10.3389/fvets.2021.679007.
  2. Reese, T., Franco, G.A., Poole, R.K., Hood, R., Fernadez, Montero L., Oliveira, Filho R.V. (2020). Pregnancy loss in beef cattle: a meta-analysis. Anim Reprod Sci., Vol. 212. DOI:10.1016/j.anireprosci.2019.106251.
  3. Wathes, D.C., Oguejiofor, C.F., Thomas, C., Cheng, Z. (2020). Importance of viral disease in dairy cow fertility. Engineering, Vol. 6, pp. 26–33. DOI:10.1016/j.eng.2019.07.0.
  4. Cuttance, E., Laven, R. (2019). Estimation of perinatal mortality in dairy calves: a review. Vet J., Vol. 252. DOI:10.1016/j.tvjl.2019.105356.
  5. Campero, C.M., Moore, D.P., Odeón, A.C., Cipolla, A.L., Odriozola, E. (2003). Aetiology of bovine abortion in Argentina. Vet Res Commun. Vol. 27, pp. 359–369. DOI:10.1023/A:1024754003432/
  6. Corbellini, L.G., Pescador, C.A., Frantz, F., Wunder, E., Steffen, D., Smith, D.R. (2006). Diagnostic survey of bovine abortion with special reference to Neospora caninum infection: importance, repeated abortion and concurrent infection in aborted fetuses in Southern Brazil. Vet J., Vol. 172, pp. 114–120. DOI:10.1016/j.tvjl.2005.03.006.
  7. Clothier, K., Anderson, M. (2016). Evaluation of bovine abortion cases and tissue suitability for identification of infectious agents in California diagnostic laboratory cases from 2007 to 2012. Theriog enology, Vol. 85, pp. 933–945. DOI:10.1016/j.ther iogenology.2015.11.001.
  8. Morrell, E.L., Moore, D.P., Odeón, A.C., Poso, M.A., Odriozola, E., Cantón, G. (2008). Retrospective study of bovine perinatal mortality: cases reported from INTA Balcarce, Argentina. Rev Argent Microbiol. Vol. 40, pp. 1571–1577.
  9. Norquay, R., Orr, J., Norquay, B., Ellis, K.A., Mee, J.F., Reeves, A. (2020). Perinatal mortality in 23 beef herds in Orkney: incidence, risk factors and aetiology. Vet Rec., Vol. 187. DOI:10.1136/vr.105536.
  10. Derzhavnyi departament veterynarnoi medytsyny. Instruktsiia pro zakhody z profilaktyky ta borotby z brutselozom tvaryn [Instructions on measures to prevent and combat animal brucellosis]. 2000. Available at:https://zakon.rada.gov.ua/laws/show/z013500#Text (date of application: 28.02.2025) (in Ukraine).
  11. Moroz, L.V., Huseinov, E.M., Kyrychenko, D.F. (2017). Zminy imunolohichnykh pokaznykiv u khvorykh na hostryi brutseloz [Changes in immunological parameters in patients with acute brucellosis]. Infektsiini khvoroby v praktytsi likaria-internista: suchasni aspekty: materialy Vseukrainskoi naukovo-praktychnoi konferentsii, m. Sumy, 25-26 travnia 2017 r. / Redkol.: M.D. Chemych, V.V. Ilina, L.V. Moroz ta in. [Infectious diseases in the practice of an internist: modern aspects: materials of the All Ukrainian scientific and practical conference, Sumy, May 25-26, 2017 / Editors: M.D. Chemych, V.V. Ilyina, L.V. Moroz and others]. Sumy: Sumy State Uni versity, pp. 187–189. (in Ukraine).
  12. Novokhatnii, Yu., Vydaiko, N., Nebohatkin, I., Bilonik, O., Svita, V. (2017). Monitorynh za infekt siiamy spilnymy dlia liudei i tvaryn (leptospiroz, brutseloz, ku-lykhomanka, skaz, sybirka) – odna zi skladovykh zabezpechennia biobezpeky naselennia Ukrainy [Monitoring of infections common to humans and animals (leptospirosis, brucellosis, K-fever, rabies, anthrax) is one of the components of ensuring biosecurity of the population of Ukraine]. Veterynarna medytsyny [Veterinary medicine]. Issue 103, pp. 58–60. (in Ukraine).
  13. Ocejo, M., Oporto, B., Hurtado, A. (2019). Occurrence of Campylobacter jejuni and Campylobacter coli in Cattle and Sheep in Northern Spain and Changes in Antimicrobial Resistance in Two Studies 10-years Apart. Pathogens, Vol. 8 (3). DOI:10.3390/pathogens8030098.
  14. Fotina, T.I., Kasianenko, O.I. (2013). Teoretychne ta eksperymentalne obhruntuvannia tekhnolohii otrymannia diahnostychnoi kampilobakterioznoi ahliutynuiuchoi syrovatky [Theoretical and experimental justification of the technology for obtaining diagnostic campylobacter agglutinating serum]. Visnyk Sumskoho natsionalnoho ahrarnoho universytetu [Bulletin of Sumy National Agrarian University]. Veterynarna medytsyna [Veterinary Medicine]. Issue 2, pp. 43–46. (in Ukraine).
  15. Sadek, S., Shaapan, R., Barakat, A. (2023). Campylobacteriosis in Poultry: A Review. The Journal of World, Vol. 13 (2), pp. 168–179. DOI:10.36380/jwpr.2023.19.
  16. Roux, F., Sproston, E., Rotariu, O., MacRae, M., Sheppard, S.K., Bessell, P., Smith-Palmer, A., Cowden, J., Maiden, M.C.J., Forbes, K.J. (2013). Elucidating the aetiology of human Campylobacter coli infections. PLoS ONE, Vol. 8. DOI:10.1371/journal.pone.0064504.
  17. Cha, W., Mosci, R.E., Wengert, S.L., Vargas, C.V., Rust, S.R., Bartlett, P.C., Grooms, D.L., Manning, S.D. (2017). Comparing the genetic diversity and antimicrobial resistance profiles of Campylobacter jejuni recovered from cattle and humans. Front. Microbiol. Vol. 8 (818). DOI:10.3389/fmicb.2017.00818.
  18. Kalinichenko, T.V., Kutsenko, V.A., Bolotin, V.I. (2020). Diahnostyka henitalnoho kampilo bakteriozu zhuinykh za reaktsii tryvaloho zviazuvannia komplementu v hospodarstvakh Ukrainy [Diagnosis of genital campylobacteriosis in ruminants by prolonged complement fixation tests in Ukrainian farms]. Veterynarna medytsyna [Veterinary Medicine]. Issue 106, pp. 55–89. DOI:10.36016/VM2020-106-10. (in Ukraine).
  19. Fang, L., Seul, L., Jessica, X., Riordan, S., Li, Z. (2022). Global epidemiology of campylobacteriosis and the impact of COVID-19. Frontiers in Cellular and Infection Microbiology. Vol. 12. DOI:10.3389/fcimb.2022.979055.
  20. Häcker, G. (2024). Chlamydia in pigs: intriguing bacteria associated with sub-clinical carriage and clinical disease, and with zoonotic potential. Front Cell Dev Biol. Vol. 14. DOI:10.3389/fcell.2024.1301892.
  21. Garvin, L.E., DeBoer, A.G., Carrell, S.J., Wang, X., Rockey, D.D. Microscopic Analysis of the Chlamydia abortus Inclusion and Its Interaction with Those Formed by Other Chlamydial Species. Infect Immun. 2022. Vol. 17. DOI:10.1128/IAI.00499-21.
  22. Ksonz, I.M., Fotina, T.I., Kassich, V.Yu., Avramenko, N.O., Milanko, H.O., Milanko, O.O., Avramenko, O.A. (2010). Khlamidiozy tvaryn: pytannia etiolohii, diahnostyky, patohenezu, profilaktyky: navch. posib. [Chlamydia of animals: issues of etiology, diagnostics, pathogenesis, prevention: a textbook]. Sumy, 112 p. (in Ukraine).
  23. Ksonz, I.M. (2012). Khlamidiozy tvaryn: monohrafiia [Chlamydiae of animals: monograph]. Poltava: Oriana, 318 p. (in Ukraine).
  24. Diakonov, L.P., Kassich, V.Yu., Fotina, T.I., Fotina, A.I., Rebenko, H.I., Milanko, H.O., Avramenko, N.O., Kassich, O.V., Volosianko, O.V. (2010). Khlamidioz tvaryn: etiolohiia, poshyrennia v pivnichno-skhidnomu rehioni Ukrainy, zasoby spetsyfichnoi profilaktyky [Chlamydiosis of animals: etiology, distribution in the north-eastern region of Ukraine, means of specific prevention]. Bulletin of the SNAU. Series "Vet. Med.", Issue № 3 (26), pp. 89–92. (in Ukraine).
  25. Instruktsiia shchodo zakhodiv z profilaktyky ta borotby z khlamidiozom silskohospodarskykh tvaryn. Nakaz Derzhavnoho departamentu veterynarnoi medytsyny 21.12.2004 № 142 [Instructions on measures to prevent and combat chlamydia in farm animals. Order of the State Department of Veterinary Medicine of 21.12.2004 No. 142]. Available at:https://zakon.rada.gov.ua/laws/show/z1652-04#Text (date of application: 27.02.2025). (in Ukraine).
  26. Pyskun, O.O., Pyskun, A.V., Ukhovskyi, V.V., Sytiuk, M.P. (2018). Etiological structure of leptospirosis among the wild boars and domestic pigs in the territory of Ukraine, its analysis and characteristics. Journal for veterinary medicine, biotechnology and biosafety, Vol. 4, pp. 5–11. (in Ukraine).
  27. Pyskun, A., Ukhovskyi, V., Pyskun, O., Nedosekov, V., Kovalenko, V., Nychyk, S., Sytiuk, M., Iwaniak, W. (2019). Presence of Antibodies Against Leptospira interrogans Serovar hardjo in Serum Samples from Cattle in Ukraine. Polish Journal of Mi crobiology, Vol. 68 (3), pp. 295–302. DOI:10.33073/pjm-2019-031. (in Ukraine).
  28. Ukhovskyi, V.V. (2017). Vyznachennia napruzhenosti ta tryvalosti imunitetu velykoi rohatoi khudoby shcheplenoi polivalentnoiu inaktyvovanoiu vaktsynoiu proty leptospirozu [Determination of the intensity and duration of immunity in cattle vaccinated with a polyvalent inactivated vaccine against leptospirosis]. Veterynarna medytsyna [Veterinary medicine]. Issue 103, pp. 219– 221. (in Ukraine).
  29. Tsarenko, T.M., Uchovskyi, V.V., Kornienko, L.E., Sachniuk, N.M., Kassich, V.Yu, Palii, A.P. (2019). Genotyping method (MLVA) of pathogenic leptospires for monitoring their distribution in tcjsystem. Ukrainian Journal of Ecology, Vol. 9, pp. 81–85. (in Ukraine).
  30. Stepna, O., Rodyna, N., Ukhovskyi, V., Kulikova, V. (2016). The research of circulation of pathogenic Leptospira among populations urban brown rats in Kyiv, Ukraine. Veterinary medicine, biotechnology and biosafety. Vol. 2 (1), pp. 5–10. (in Ukraine).
  31. Vovk, L.M. (2009). Listerioz (ohliad literatury) [Listeriosis (literature review)]. Klinichna immunolohiia [Clinical immunology]. Alerholohiia [Allergology]. Infektolohiia [Infectology]. Available at:https://salo.li/80A3b5E (date of application: 25.02.2025). (in Ukraine).
  32. Korovin, I.V. (2012). Osnovni shliakhy eradykatsii listeriozu silskohospodarskykh tvaryn v Ukraini [Main ways to eradicate listeriosis in farm animals in Ukraine]. Veterynarna medytsyna [Veterinary medicine]. Issue 96, pp. 212–216. (in Ukraine).
  33. Ukhovska, T.M., Horbatiuk, O.I., Harkavenko, T.O., Ryzhenko, H.F., Andriiashchuk, V.O., Zhovnir, O.M., Tiutiun, S.M. (2017). Monitorynh listeriozu tvaryn ta zasoby yoho profilaktyky dlia pidtrymannia biobezpeky v Ukraini [Monitoring of animal listeriosis and means of its prevention to maintain biosecurity in Ukraine]. Veterynarna medytsyna [Veterinary medicine]. Issue 103, pp. 222–226. (in Ukraine).
  34. Pyskun, O., Horbatiuk, O., Musiiets, I., Shalimova, L., Balanchuk, L., Ordynska, D., Mekh, N., Chechet, O. (2023). Mikrobiolohichnyi monitorynh listeriozu v Ukraini za period 2018–2022 rr [Microbiological monitoring of listeriosis in Ukraine for the period 2018–2022]. One Health Journal, Issue 1, pp. 19–28. DOI:10.31073/onehealthjournal2023-III-03. (in Ukraine).
  35. Polishchuk, I.V. (2018). Rol i mistse vaktsyn proty listeriozu u systemi zabezpechennia blahopoluchchia tvaryn [The role and place of listeriosis vaccines in the animal welfare system]. Veterynarna biotekhnolohiia [Veterinary biotechnology]. Issue 32, pp. 416–424. DOI:10.31073/vet_ biotech32(1)-55. (in Ukraine).
  36. Gürcan, S. (2014). Epidemiology of tularemia. Balkan Med J., Vol. 31, pp. 3–10. DOI:10.5152/balkanmedj.2014.13117.
  37. Colquhoun, D.J., Duodu, S. (2011). Francisella infections in farmed and wild aquatic organisms. Vet Res. Vol. 42. DOI:10.1186/1297-9716-42-47.
  38. Maurin, M., Pondérand, L., Hennebique, A., Pelloux, I., Boisset, S., Caspar, Y. (2024). Tularemia treatment: experimental and clinical data. Front Microbiol. Vol. 14. DOI:10.3389/fmicb.2023.1348323.
AttachmentSize
PDF icon kassich_1_2025.pdf672.11 KB