You are here
Integral indexes of intoxication in caninae coronaviridae enteritis
In this article to be spoken about indicators of action of coronaviridae on an organism of animals – qualitative and quan-titative characteristics of blood. These indicators change at many patological reactions and participate in ensuring nonspe-cific and specific resistance of an organism.
With the help of the analysis of integral leukocyte indices based on the formula of blood reflecting the state of neurohumoral homeostasis and immunological reactivity of the organism, the violations were first discovered and established humoral and cellular links of the immune system, micro- and macrophage system, reduction of nonspecific protection of the organism and revealed connections between integral hematological parameters and immunity indexes in dogs with experimental and natural infection with coronavirus.
In animals in the natural course of coronavirus enteritis there were changes in the indexes of intoxication: a significant increase in the leukocyte index of intoxication, the indicator of reactivity of the organism, the index of leukocyte shift of blood and the index of intoxication, and significant decrease in the nuclear index, the general index and the leukocyte index in indices of nonspecific reactivity, a significant increase in the ratio of neutrophils and lymphocytes, the ratio of neutrophils and monocytes, the ratio of eosinophils to leukocytes and the ratio of segmental neutrophils and bands neutrophils, a significant decrease in the ratio of lymphocytes and monocytes, the index of ratio of lymphocytes and eosinophils, the index of Garkavy, index allergy and immunoreactivity index in indexes of activity of inflammation, a significant decrease of the ratio of leukocytes and ЕSR, the lymphocytic granulocytic index and the ratio of lymphocytes and monocytes to the ESR.
Experimental infection revealed changes in the indexes of intoxication: a significant increase in the leukocyte index of intoxication, the nuclear index and the index of blood leukocyte shift, a significant decrease in the indicator of reactivity of the organism, the general index, the leukocyte index and the indicator of intoxication in the indices of nonspecific reactivity, a significant increase in the ratio of neutrophils and lymphocytes to the index ratio of eosinophils to leukocytes, a significant decrease in the ratio of lymphocytes and monocytes, the index of ratio of lymphocytes and eosinophils, the Garkavy index, the ratio of segmental neutrophils and bands neutrophils and the index of immunoreactivity in the activity indices, a significant decrease in the ratio of leukocytes and ESR and lymphocytic granulocytic index.
Integral hematological parameters of peripheral blood have been proved to increase the informative value of the general analysis of blood in dogs with infectious diseases and allow to determine not only the degree of reactivity of the organism, but also to assess the level of endogenous intoxication.
Key words: coronavirus enteritis, natural infection, experimental infection, hematological indices.
1. Garkavi, L.KH., Kvakina, Ye.B., Kuz'menko, T.S. (1998). Antistressornyye reaktsii i aktivatsionnaya terapiya [Antistress reactions and activation therapy], Moscow : Imedis, 654p.
2. Grin', V.K., Fistal', E.YA., Speranskiy, I.I. (2006). Integral'nyye gematologicheskiye pokazateli leykotsitarnoy formuly kak kriteriy otsenki tyazhesti techeniya ozhogovoy bolezni, yeye oslozhneniy i effektivnosti provodimogo lecheniya [Integral hematological indices of leukocyte formula as a criterion for assessing the severity of the course of a burn disease, its complications and the effectiveness of the treatment provided]. Materialy nauch.-prakt. konf. «Sepsis: problemy diagnostiki, terapii i profilaktiki», 29‒30 marta 2006 [Materials nauch.-practical. conf. “Sepsis: problems of diagnosis, therapy and prevention”, March 29-30, 2006], Khar'kiv, pp. 77‒78.
3. Derkho, M.A., Samoylova, Ye.S. (2011). Integral'nyye indeksy intoksikatsii kak kriteriy otsenki urovnya endogennoy intoksikatsii pri babezioze [Integral intoxication indices as a criterion for assessing the level of endogenous intoxication in babesiosis]. Uchenyye zapiski KGAVM im. N.E. Baumana [Scientific notes KGAVM them. N.E. Bauman], Vol. 207, pp. 170‒177.
4. Godlevs'kiy, A.Í., Savolyuk, S.Í. (2015). Díagnostika ta monítoring yendotoksikozu u khírurgíchnikh khvorikh [Diagnosis and monitoring of endotoxicosis in chronic diseases], Vinnitsa, The New Book, 232 p.
5. Horalʹsʹkyy, L.P., Radzykhovsʹkyy, M.L., Dyshkant, O.V. (2018). Intehralʹni hematolohichni indeksy otsinky stupenya endohennoyi intoksykatsiyi u sobak [Integral hematological indices for assessing the degree of endogenous intoxication in dogs]. Metodical recommendations. Zhytomyr, 28.p.
6. Ivanov, D.O., Shabalov, N.P., Shabalova, N.N. (2002). Leykotsitarnyye indeksy kletochnoy reaktivnosti kak pokazatel' nalichiya gipo- i giperergicheskogo variantov neonatal'nogo sepsisa [Leukocyte indices of cellular reactivity as an indicator of the presence of hypo-and hyper-allergic variants of neonatal sepsis]. Opyt lecheniya detey v mnogoprofil'noy detskoy bol'nitse : sb. SPb., [Experience of treating children in a multi-disciplinary children's hospital: Sat. SPb.,]. pp. 22‒28.
7. Luk’yanchuk, V.D., Míshchenko, K.M. (2002). Noví shlyakhi farmakorektsíí̈ yendotoksikozu, shcho razvivayut'sya pri travmatichnomu shoku [New pharmaceutical pharmaco-endehyde endotoxicosis develops with traumatic shock]. Trudi ÍKH kongresu SFULT [Proceedings of the First Congress of the SFULT]. Lugansk, pp. 430‒431.
8. Kochetov, A.G., Lyang, O.V., Masenko, V.P. (2012). Metody statisticheskoy obrabotki meditsinskikh dannykh: Metodicheskiye rekomendatsii dlya ordinatorov i aspirantov meditsinskikh uchebnykh zavedeniy, nauchnykh rabotnikov [Methods of statistical processing of medical data: Methodical recommendations for residents and postgraduates of medical schools, researchers]. Moscow, RCNPK, 42 p.
9. Nikiforov, A. (2010). Nevrologiya. Polnyy tolkovyy slovar' [Neurology. Full Explanatory Dictionary]. Moscow, Exmo, 464 p.
10. Ostrovskiy, V.K. (2003). O pokazatelyakh normy leykotsitarnogo indeksa intoksikatsii [About indicators of the norm of leukocyte index of intoxication]. Klinicheskaya laboratornaya diagnostika [Clinical laboratory diagnosis]. Vol. 1, pp. 45–46.
11. Ostrovskiy, V.K., Mashchenko, A.V., Yangolenko, D.V., Makarov, S.V. (2006). Pokazateli krovi i leykotsitarnogo indeksa intoksikatsii v otsenke tyazhesti i opredelenii prognoza pri vospalitel'nykh, gnoynykh i gnoynodestruktivnykh zabolevaniyakh [ Blood and leukocyte index of intoxication in assessing the severity and determining the prognosis for inflammatory, purulent and purulent-destructive diseases]. Klin. lab. Diagnostika [Wedge. lab diagnostics]. Vol. 6, pp. 50–53.
12. Sakovich, A.R. (2012). Gematologicheskiye leykotsitarnyye indeksy pri ostrom gnoynom sinusite [Hematological leukocyte indices in acute purulent sinusitis]. UO «Belorusskiy gosudarstvennyy meditsinskiy universitet» [EE "Belarusian State Medical University"]. pp. 89 – 91.
13. Svetukhin, A.M., Zvyagin, A.A., Slepneva, S.YU. (2002). Integral'nyye sistemy v otsenke tyazhesti bol'nykh s gnoynoy patologiyey [Integral systems in assessing the severity of patients with purulent pathology]. Khirurgiya. Zhurnal im. N.I. Pirogova [Surgery. Journal them. N.I. Pirogov]. Vol. 9, pp. 51–57.
14. Speranskiy, I.I., Samoylenko, G.Ye., Lobacheva, M.V. (2009). Obshchiy analiz krovi ‒ vse li yego vozmozhnosti ischerpany? Integral'nyye indeksy intoksikatsii kak kriterii otsenki tyazhesti techeniya endogennoy intoksikatsii, yeye oslozhneniy i effektivnosti provodimogo lecheniya [Complete blood count – are all his options exhausted? Integral intoxication indexes as criteria for assessing the severity of endogenous intoxication, its complications and the effectiveness of the treatment]. Zdorov'ye Ukrainy [Health of Ukraine]. Vol. 6 (19), pp. 51‒57.
15. Khabirov, T.SH. (2002). Uroven' reaktivnogo otveta neytrofilov kak pokazatel' stepeni tyazhesti endogennoy intoksikatsii pri abdominal'nom sepsise [The level of reactive response of neutrophils as an indicator of the severity of endogenous intoxication in abdominal sepsis]. Trudi ÍKH kongresu SFULT [Trudy IX Congress SFULT]. Lugansk, 223 p.
16. Bel’skaya, L.V., Kosenok, V.K., Massard, G. (2016). Endogenous intoxication and saliva lipid peroxidation in patients with lung cancer J. Diagnostics 6 (4). https://doi.org/10.3390/diagnostics6040039
17. Gutyj, B., Grymak, Y., Drach, M., et al. (2017). The impact of endogenous intoxication on biochemical indicators of blood of pregnant cows. Regulatory Mechanisms in Biosystems, 8(3), pp. 438–443.
18. Lobo, A., Vinodkumar, K., Tresamol, P.V., Justin Davis, K., Priya, P.M. (2017). Hematological changes in dogs with parvovirus enteritis in thrissur district / Imperial journal of interdisciplinary research. 3 (6), pp. 1323‒1325
| Attachment | Size |
|---|---|
 visnyk_vet-2-2018-radzyhovskyy-13-19.pdf | 354.89 KB |