The article presents a comprehensive analysis of current data on clostridioses in animal husbandry, focusing on pathogens of the genus Clostridium, including C. perfringens, C. chauvoei, C. septicum, C. difficile and C. botulinum. The study addresses the etiological, cultural-morphological, and toxin producing properties of clostridia, factors infl uencing their epizootic spread, as well as modern methods of laboratory diagnostics and prevention. The aim of the research was to summarize scientifi c evidence on toxin polymorphism, antimicrobial resistance, zoonotic potential, and control strategies for clostridial infections in animals. The study employed analytical and comparative methods to review recent scientifi c publications, international and national databases (PubMed, Scopus, Web of Science, Google Scholar), and offi cial materials from Food and Agriculture Organization, World Health Organisation, World Organisation for Animal Health, , as well as Ukrainian veterinary regulations and food safety standards. Special attention was paid to combined diagnostic approaches, including culture-based methods, PCR, and molecular typing of toxin genes, alongside preventive measures such as vaccination, feed optimization, biosecurity, and probiotic supplementation. Results indicate that clostridia are highly ecologically adaptable, persisting in soil, feed, and the intestines of animals. C. perfringens remains a major causative agent of enterotoxemia, necrotic enteritis, and myonecrosis in various species, with NetB toxin in poultry and β-toxin in swine determining the severity of clinical signs. C. chauvoei and C. septicum cause acute histiotoxic infections with high mortality in cattle and small ruminants. Toxigenic C. difficile strains demonstrate zoonotic potential, circulating between animals and humans. The prevalence of multidrug-resistant C. perfringens strains complicates treatment and emphasizes the need for continuous antimicrobial resistance monitoring. Effective prevention of clostridioses requires an integrated approach combining control of toxigenic strains, vaccination, feed management, biosecurity measures, and the use of probiotics, which reduces morbidity and mortality in livestock and improves the safety of animal products.

Keywords: Clostridium spp., clostridioses, toxigenicity, multidrug resistance, laboratory diagnostics, prevention, animal husbandry, probiotics, zoonoses.