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Antigenic activity of experimental series of inactivated vaccines against highly pathogenic avian influenza with dif-ferent levels of hemagglutinins
In the results of studies it was examined antigenic activity of experimental series of inactivated vaccine against highly pathogenic avian influenza with different levels of hemagglutinin. The dependence of the antigenic properties of the vaccine on the hemagglutinin levels in inactivated antigens, which are part of the vaccine was established. Thus, in chickens vaccinated twice with vaccines against highly pathogenic avian influenza with hemagglutinin level since 1:512 to 1:128, the average level of antibodies was 9,0 ± 0,77 – 7,66 ± 0,44 log2 in 30 days after vaccination. At the same time using the vaccine for the vaccination of chickens with the hemagglutinin level 1:64 average antibody level was 5,0 ± 1,41 log2. It was determined that the hemagglutinin level in inactivated antigens for vaccines should not be lower then 1:512, and optimal titer is 1:1024–1:2048, which can provide a high level of protection at vaccinated birds.
Key words: highly pathogenic avian influenza, vaccine, specific antibody level, the activity of inactivated antigens.
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