You are here

Hepatodystrophy of high-productive cows

The fat hepatodystrophy is a very frequent pathology of highly productive cows, it is registered at 50–90 % of animals. The disease is complicated by the affect of hart, kidneys, legs, endocrine system, by secondary osteodystrophy, which reduces the duration of valuable herd exploitation.

The reason of the primary hepatodystrophy is a disturbance of cows feeding especially during first 2-3 months of lactation: а) energy deficiency in ration and excess of protein; b) deficiency of methionine, choline and natural anti-oxidants in feeds; c) feeding by low quality, nasty (mouldy, rotten) feeds. The secondary hepatodystrophy is related to ketosis, obesity, chronic acidosis, abomasum displacement and other internal, surgical and gynaecological diseases which decrease fodders intake. Then, the lipomobilisation syndrome appears and induces an intense fat deposition into hepatocytes. The negative energetic balance develops, its duration and evidence depend on cows’ productivity.

For diagnostic of the hepatodystrophy caws’ productivity, structure and full value of rations, feeds quality, disease symptoms and results of laboratory analysis of blood serum are taken into account.

The treatment of caws with the hepatodystrophy should be complex, it foresees the respect of diet, the ration containing green fodders, hay, corn and barley offal, 1,5-2 kg of molasses. As for drugs, products restoring metabolism in hepatocytes, vitamins, hepatoproterctors, antioxidants, glucoplastic and bile-expelling products are used. For normalization of gluconeogenesis and reducing fats income into liver when breakdown of fat is intense, glucoplastic drugs, lipotropic products and hepatoprotectors are induced. The treatment duration of caws with a mild case of hepatodystrophy (7-12 % of fat against the weight of liver) should be 8 – 10 days, as for caws with a moderate case (until 25 % of fat) the treatment duration should be 10 – 25 days. As for severe cases of liver fatty degeneration that is usually accompanied by ketosis, hypotony of proventricula and chronic rumen acidosis the treatment is not efficient.

The prophylaxis of the hepatodystrophy is based on the complex approach to animal health control. One of its components is the organization of well-balances feeding by high quality feeds, it is the most important for heifers and caws of first calving during dry period and first 80 – 100 days after lactation. A special attention should be paid to the content of sugar and starch in rations and their ratio to digestible protein, as well as to optimal energy supply of heifers and caws.

The efficient mean for the prophylaxis of liver pathology and other diseases of highly productive caws such as ketosis, rumen acidosis, proventricula hypotony, secondary osteodystrophy and others is feeding according to phases. It consists of 5 – 6 periods: early and late dry periods (respectively 60-20 and 20-1 days before foreseen calving), after calving (2-3 weeks after calving), early lactation (till 80-110 days), medium and late lactation (the duration of every lactation is about 100 day). A special attention should be paid to so called « transitory period » (last three weeks before foreseen calving and first weeks after calving) and to period of early lactation. The rations at these periods should correspond to physiological condition, productivity and lactation period of highly productive caws. One of the efficient prophylaxis measures is the implementation of feeds mixture containing in equal parts roughage (hay, straw), succulent feeds (silage, haylage) and concentrated feeds (corn, barley, wheat, soybeans, sunflower cake etc.) with the part of dry matter up to 50% for feeding heifers and caws. Some farmers include green feeds into the ration during spring and summer period but their part is up to 15-20 %.

Key words: high-productive cows, hepatodystrophy, ketosis, metabolism, nutrition, aethiology, pathogenesis, diagnostics, treatment, prophylaxis

1. Kondrakhin, І.P., Levchenko, V.І. (2000). Fiziologichni osnovy profilaktyky vnutrishnih hvorob [Physiological bases for the prophylaxis of internal diseases]. Visnyk agrarnoi' nauky [Digest of agrarian science], no. 2, pp. 33-35.

2. Yanovych, V.G., Sologub, L.І. (2000). Biologichni osnovy transformacii' pozhyvnyh rechovyn u zhujnyh tvaryn [Biological bases of the transformation of nutrients at ruminants]. Lviv, Triada plus, 384 p.

3. Levchenko, V.І., Sakhnyuk, V.V. (2001). Etiologija, patogenez ta diagnostyka vnutrishnih hvorob u vysokoproduktyvnyh koriv [Etiology, pathogenesis and diagnostic of internal diseases at highly productive caws]. Visnyk agrarnoi' nauky [Digest of agrarian science], no. 10, pp. 28-32.

4. Sakhnyuk, V.V., Levchenko, V.І., Chub, О.V. (2015). Profilaktyka mnozhynnoi' vnutrishn'oi' patologii' u vysokoproduktyvnyh koriv [Prophylaxis of multiple internal pathology at highly productive caws]. Nauk. visnyk vet. medycyny [Scientific digest of veterinary medicine], Edition 1 (118), Bila Tserkva, pp.30-37.

5. Andreaws T. (1998). Ketosis and fatty liver in cattle. In. Practice, no. 20 (9), pp. 509–513.

6. Vlizlo, V., Sukhodolska, M. (2004). Stan der Saure-Base-Haushalt im Blut von Kuhen abhangig von der Konzentration von Ketonkorpem im Blut und Urinn. V Symposium Ukraine-Austria: Agricalture, Sciense and Practice, Kyiv,pp. 64-65.

7. Levchenko, V.І., Vlizlo, V.V. (1998). Diagnostyka, likuvannja ta profilaktyka hvorob pechinky u velykoi' rogatoi' hudoby (metodychni rekomendacii') [Diagnostic, treatment and prophylaxis of liver diseases at cattle (Methodological recommendations)], К., 22 p.

8. Levchenko, V.I., Kondrakhin, I.P., Sakhnyuk, V.V. (2007). Vnutrishni hvoroby vysokoproduktyvnyh koriv (etiologija, diagnostyka, likuvannja i profilaktyka) [Internal diseases of highly productive caws (etiology, diagnostic, treatment and prophylaxis)]. Metod. rekomendacii' [methodological recommendations], Bila Tserkva, 105 p.

9. Sakhnyuk V.V. (2009). Polimorbidnist' vnutrishn'oi' patologii' u vysokoproduktyvnyh koriv (eksperymental'ne ta teoretychne obg'runtuvannja patogenezu, metodiv diagnostyky, likuvannja i profilaktyky) [Polymorbidity of internal pathology at highly productive caws (experimental and theoretical justification of pathogenesis, diagnostic methods, treatment and prophylaxis)]. Dys. d-ra vet. nauk [Thesis of doctor of veterinary sciences], Bila Tserkva, 324 p.

10. Levchenko, V.I., Vlizlo, V.V., Golovakha, V.I. (1996). Patologija pechinky u velykoi' rogatoi' hudoby [Liver pathology at cattle]. Visnyk agrar. nauky [Digest of agrarian science], К., Urozhay, no. 9, pp. 50-54.

11. Levchenko, V.I., Kondrakhin, I.P., Bogatko, L.М. (2000). Dyspanseryzacija sil's'kogospodars'kyh tvaryn. Zagal'na terapija i profilaktyka vnutrishnih hvorob tvaryn: praktykum [Healthy survey of agricultural animals. General therapy and prophylaxis of internal diseases: practice], Bila Tserkva, pp. 176-205.

12. Levchenko, V.I., Kondrakhin, I.P., Vlizlo, V.V. (2012). Vnutrishni hvoroby tvaryn [Internal diseases of animals], Bila Tserkva, P. 1, 528 p.

13. Levchenko, V.I., Dostoyevsky, P.P., Sakhnyuk, V.V. (2005). Dyspanseryzacija vysokoproduktyvnyh koriv – zaporuka uspishnogo vedennja molochnogo tvarynnyctva [Healthy survey of highly productive caws as a guarantee of successful dairy husbandry]. Vinyk Bilocerkiv. derzh. agrarn. un-tu [Digest of Bila Tserkva national agrarian university], Edition 33, Bila Tserkva, pp. 135–144.

14. Bogdanov, G.О., Kandyba, V.М., Ibatulin, І.І. Kostenko, V.І. (2012). Teorija i praktyka normovanoi' godivli velykoi' rogatoi' hudoby [Theory and practice of normalized cattle feeding], Zhytomyr, 860 p.

15. Ibatulin, І.І., Bashchenko, М.І., Zhukorsky, О.М. (2016). Dovidnyk z povnocinnoi' godivli sil's'kogospodars'kyh tvaryn [Guide for full value feeding of agricultural animals], К., Agrarian science, 336 p.

16. Vlizlo, V.V., Kurtyak, B.М., Vudmaska, І.V. (2015). Zhyrorozchynni vitaminy u veterynarnij medycyni ta tvarynnyctvi [Fat soluble vitamins at veterinary medicine and animal husbandry], Lviv, SPOLOM, 436 p.

17. Кlitsenko G.Т., Kulyk М.F., Коsenko М.V. (2001). Mineral'ne zhyvlennja tvaryn [Mineral nutrition of animals], К., Svit, 575 p.

18. Levchenko, V.I., Golovakha, V.I., Kondrakhin, I.P. (2010). Metody laboratornoi' klinichnoi' diagnostyky hvorob tvaryn [Methods of laboratory and clinical diagnostic of animal diseases], К.,Agrarian education, 437 p.

19. Kondrakhin, I.P., Arkhipov, A.V., Levchenko, V.I. (2004). Metody veterinarnoj klinicheskoj laboratornoj diagnostiki: spravochnik [Methods of veterinary laboratory and clinical diagnostic: guide], M., Kolos, 520 p.

20. Levchenko, V.I., Vlizlo, V.V., Kondrakhin, I.P. (2015). Vnutrishni hvoroby tvaryn [Internal diseases of animals], Bila Tserkva, P. 2, 610 p.

21. Levchenko, V.I., Vlizlo, V.V., Kondrakhin, I.P. (2002). Veterynarna klinichna biohimija [tekst]: pidruchnyk [Veterinary clinical biochemistry [text]: manual], Bila Tserkva, 400 p.

22. Vlizlo, V.V., Halterskinen, M., Scholtz, G. (2001). Porushennja godivli koriv – prychyna zahvorjuvanosti [Distortion of caws feeding as a reason of diseases]. Vet. medycyna Ukrai'ny [Veterinary medicine of Ukraine],no. 5, 38 p.

23. Espocito, G., Irons, P.S,. Webb, E.C,. Chapwanya, A. (2004). Interactions between negative energy balance, metabolic diseases, uterine health and immune response in transition dairy cows. Animal Reproductive Sciense, no. 144 (3–4), pp. 60–71.

24. Grummer, R.R., Mashek, D.G., Hayirli, A. (2004). Dry matter intake and energy balance in the transition period. Veter. Clinics of North America: Food Animal Practice, no. 20 (4), pp. 447– 470.

25. Melender, P.,. Risco, C.A, (2005). Management of transition cows to optimize reproductive officiency in dairy herds. Veter. Clinics of North America: Food Animal Practice, no. 21 (2), pp. 485– 501.

26. Kondrakhin I.P. (2010). Metabolycheskyj syndrom: sovremennoe predstavlenye, perspektyv yspol'zovanyja [Metabolic syndrome: actual comprehension, perspectives of using]. Biologija tvaryn. [Biology of animals], V. 12, no. 2, pp. 63–66.

27. Carlos A. Risco, (2011). Pedro Melendez Retamal. Dairy Production Medicine. – Wiley-Blackwell, 345 p.

28. Warren H. (2016). Preventing common metabolic disorders in dairy cattle. Dairy Cattle (ruminant health and nutrition), no. 3, pp. 196–213.

29. Pavlov, М.Y., Mytrofanov, О.V., Pasichnyk, V.А. (2016). Zminy energetychnogo balansu u koriv ta i'h naslidky [Changes of energy balance in caws and their consequences]. Zb. nauk. prac' Harkivs'koi' derzh. zoo-vet. akad.: vet. nauky [Collection of scientific editions of Kharkiv state zoo-veterinary academy: veterinary sciences], Edition. 32, P. 2, Kharkiv, pp.16–22.

30. Sakhnyul V.V. (2001). Informacijnist' koaguljacijnyh reakcij dlja diagnostyky hvorob pechinky u vysokoproduktyvnyh koriv [Information content of caogulative reactions for diagnostic of liver diseases at highly productive caws]. Visnyk Bilocerkiv. derzh. agrar. un-tu [Digest of Bila Tserkva national agrarian university], Edition 18, Bila Tserkva, pp. 124–131.

31. Levchenko, V.I., Sakhnyuk, V.V. (2000). Fermentodiagnostyka vnutrishnih hvorob u vysokoproduktyvnyh koriv [Enzymo-diagnostic of internal diseases at highly productive caws]. Visnyk Bilocerkiv. derzh. agrar. un-tu [Digest of Bila Tserkva national agrarian university], Edition 13, part 2, Bila Tserkva, pp. 116-124.

32. Sakhnyul V.V., Sahnjuk V.V. (2008). Parametry ocinky kliniko-funkcional'nogo stanu pechinky i nyrok u klinichno zdorovyh vysokoproduktyvnyh koriv [Evaluation parameters of clinical and functional condition of liver and kidneys at clinically healthy highly productive caws]. Visnyk Bilocerkiv. derzh. agrar. un-tu [Digest of Bila Tserkva national agrarian university], Edition 51, Bila Tserkva, pp. 78 – 85.

33. Levchenko, V.I., Sakhnyuk, V.V., CHUB, O.V. (2009). Gepatodystrofija vysokoproduktyvnyh koriv [Hepatodystrophy of highly productive caws]. Zdorov’ja tvaryni i liky [Animal health and drugs],no. 3 (88), pp. 14–16.

34. Sakhnyuk V.V. (2017). Polimorbidna patologija vysokoproduktyvnyh koriv: rozpochaty dijaty [Polymorbid pathology of highly productive caws : to start to act]. Tvarynnyctvo. Veterynarija [Animal husbandry], Veterinary medicine, no. 9, pp.44–47.

AttachmentSize
PDF icon nvvm_1_2017_p82-89_sahnuk.pdf606.37 KB